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Transcriptional Regulation of the Warburg Effect in Cancer by SIX1

Overview of attention for article published in Cancer Cell, February 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Average Attention Score compared to outputs of the same age and source

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1 news outlet
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25 X users
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1 Facebook page

Citations

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272 Dimensions

Readers on

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183 Mendeley
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Title
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1
Published in
Cancer Cell, February 2018
DOI 10.1016/j.ccell.2018.01.010
Pubmed ID
Authors

Ling Li, Yingchun Liang, Lei Kang, Yang Liu, Shan Gao, Siyu Chen, Ying Li, Wenye You, Qian Dong, Tian Hong, Zhifeng Yan, Shuai Jin, Tao Wang, Wei Zhao, Haixing Mai, Jun Huang, Xiao Han, Quanbo Ji, Qi Song, Chao Yang, Shixin Zhao, Xiaojie Xu, Qinong Ye

Abstract

Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown. Here we show that transcription factor SIX1 directly increases the expression of many glycolytic genes, promoting the Warburg effect and tumor growth in vitro and in vivo. SIX1 regulates glycolysis through HBO1 and AIB1 histone acetyltransferases. Cancer-related SIX1 mutation increases its ability to promote aerobic glycolysis and tumor growth. SIX1 glycolytic function is directly repressed by microRNA-548a-3p, which is downregulated, inversely correlates with SIX1, and is a good predictor of prognosis in breast cancer patients. Thus, the microRNA-548a-3p/SIX1 axis strongly links aerobic glycolysis to carcinogenesis and may become a promising cancer therapeutic target.

X Demographics

X Demographics

The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 183 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 36 20%
Researcher 24 13%
Student > Bachelor 18 10%
Student > Master 14 8%
Student > Doctoral Student 9 5%
Other 31 17%
Unknown 51 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 53 29%
Agricultural and Biological Sciences 27 15%
Medicine and Dentistry 21 11%
Pharmacology, Toxicology and Pharmaceutical Science 7 4%
Neuroscience 4 2%
Other 16 9%
Unknown 55 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2021.
All research outputs
#1,702,797
of 25,382,440 outputs
Outputs from Cancer Cell
#1,153
of 3,149 outputs
Outputs of similar age
#42,307
of 470,360 outputs
Outputs of similar age from Cancer Cell
#36
of 61 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 470,360 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.