Title |
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1
|
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Published in |
Cancer Cell, February 2018
|
DOI | 10.1016/j.ccell.2018.01.010 |
Pubmed ID | |
Authors |
Ling Li, Yingchun Liang, Lei Kang, Yang Liu, Shan Gao, Siyu Chen, Ying Li, Wenye You, Qian Dong, Tian Hong, Zhifeng Yan, Shuai Jin, Tao Wang, Wei Zhao, Haixing Mai, Jun Huang, Xiao Han, Quanbo Ji, Qi Song, Chao Yang, Shixin Zhao, Xiaojie Xu, Qinong Ye |
Abstract |
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown. Here we show that transcription factor SIX1 directly increases the expression of many glycolytic genes, promoting the Warburg effect and tumor growth in vitro and in vivo. SIX1 regulates glycolysis through HBO1 and AIB1 histone acetyltransferases. Cancer-related SIX1 mutation increases its ability to promote aerobic glycolysis and tumor growth. SIX1 glycolytic function is directly repressed by microRNA-548a-3p, which is downregulated, inversely correlates with SIX1, and is a good predictor of prognosis in breast cancer patients. Thus, the microRNA-548a-3p/SIX1 axis strongly links aerobic glycolysis to carcinogenesis and may become a promising cancer therapeutic target. |
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Geographical breakdown
Country | Count | As % |
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United States | 5 | 20% |
France | 3 | 12% |
Canada | 2 | 8% |
United Kingdom | 2 | 8% |
Spain | 2 | 8% |
India | 1 | 4% |
Monaco | 1 | 4% |
Unknown | 9 | 36% |
Demographic breakdown
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Members of the public | 17 | 68% |
Scientists | 6 | 24% |
Science communicators (journalists, bloggers, editors) | 2 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 183 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 36 | 20% |
Researcher | 24 | 13% |
Student > Bachelor | 18 | 10% |
Student > Master | 14 | 8% |
Student > Doctoral Student | 9 | 5% |
Other | 31 | 17% |
Unknown | 51 | 28% |
Readers by discipline | Count | As % |
---|---|---|
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Agricultural and Biological Sciences | 27 | 15% |
Medicine and Dentistry | 21 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
Neuroscience | 4 | 2% |
Other | 16 | 9% |
Unknown | 55 | 30% |