Title |
Second re-irradiation for DIPG progression, re-considering “old strategies” with new approaches
|
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Published in |
Child's Nervous System, March 2017
|
DOI | 10.1007/s00381-017-3352-y |
Pubmed ID | |
Authors |
Andres Morales La Madrid, Vicente Santa-María, Ofelia Cruz Martinez, Jaume Mora, Patricia Puerta Roldan, Antonio Guillen Quesada, Mariona Suñol Capella, Carmen de Torres Gomez-Pallete, Alvaro Lassaletta, Normand Laperriere, Salvador Villà, Eric Bouffet |
Abstract |
Diffuse intrinsic pontine glioma (DIPG) is an aggressive infiltrative glioma for which no curative therapy is available. Radiation therapy (RT) is the only potentially effective intervention in delaying tumor progression, but only transiently. At progression, re-irradiation is gaining popularity as an effective palliative therapy. However, at second progression, exclusive symptomatic treatment is usually offered. Here we report two patients with DIPG at second progression who were treated with a second re-irradiation course with good response. Importantly, treatment was well tolerated with no irradiation associated acute toxicity identified. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 41 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 8 | 19% |
Researcher | 5 | 12% |
Student > Doctoral Student | 5 | 12% |
Student > Bachelor | 3 | 7% |
Student > Master | 3 | 7% |
Other | 8 | 19% |
Unknown | 10 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 52% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Agricultural and Biological Sciences | 2 | 5% |
Neuroscience | 1 | 2% |
Unspecified | 1 | 2% |
Other | 0 | 0% |
Unknown | 14 | 33% |