| Title |
Effect of selective serotonin reuptake inhibitors on bone mineral density: a systematic review and meta-analysis
|
|---|---|
| Published in |
Osteoporosis International, February 2018
|
| DOI | 10.1007/s00198-018-4413-0 |
| Pubmed ID | |
| Authors |
C. Zhou, L. Fang, Y. Chen, J. Zhong, H. Wang, P. Xie |
| Abstract |
Our work is the first systematic meta-analysis to investigate the effect of selective serotonin reuptake inhibitor (SSRI) medication on bone mineral density. Through meta-analyzed 11 studies, our findings suggested that compared with nonusers, use of SSRIs was significantly associated with lumbar spine BMD reduction, particularly for old people. The use of selective serotonin reuptake inhibitors (SSRIs) has already been associated with bone mass loss. Their effects on bone mineral density (BMD) for the different bone sections have, however, thus been inconsistent. Here, we aim to assess the effects of SSRIs on BMD using a meta-analysis. We searched PubMed, Scopus, ISI Web of Knowledge, the Cochrane Library, and PsycINFO for all English-written studies investigating the effects of SSRIs on BMD and published before November 2017. BMD was compared between non-SSRI users and SSRI users using a random-effect model with standardized mean differences (SMD) and 95% confidence intervals (CIs). Furthermore, subgroup analyses were performed based on study design, age, and sex in order to find the origins of high heterogeneity. Eleven studies met the inclusion criteria and were used for the meta-analysis. Our study demonstrated that the use of SSRIs was significantly associated with lower BMD values (SMD - 0.40; 95% CI - 0.79 to 0.00; p = 0.05) and BMD Z-scores (SMD - 0.28; 95% CI - 0.50 to - 0.05; p = 0.02) of the lumbar spine, but not of the total hip and femoral neck. In addition, SSRI use was associated with a greater bone loss in older people. SSRI use is a risk factor of lower BMD of the lumbar spine, especially for older people. Future studies into the relationship between SSRI use and bone metabolism and bone mass need to be conducted with larger sample sizes for both men and women at different bone sites. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 4 | 17% |
| United Kingdom | 3 | 13% |
| United States | 2 | 9% |
| New Zealand | 1 | 4% |
| Switzerland | 1 | 4% |
| Netherlands | 1 | 4% |
| Spain | 1 | 4% |
| Argentina | 1 | 4% |
| Colombia | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 6 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 78% |
| Scientists | 2 | 9% |
| Practitioners (doctors, other healthcare professionals) | 2 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 8 | 15% |
| Student > Ph. D. Student | 6 | 11% |
| Student > Postgraduate | 5 | 9% |
| Researcher | 4 | 7% |
| Professor | 2 | 4% |
| Other | 6 | 11% |
| Unknown | 23 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 26% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Nursing and Health Professions | 2 | 4% |
| Business, Management and Accounting | 1 | 2% |
| Other | 6 | 11% |
| Unknown | 26 | 48% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2024.
All research outputs
#2,070,193
of 25,874,560 outputs
Outputs from Osteoporosis International
#334
of 3,888 outputs
Outputs of similar age
#47,951
of 457,972 outputs
Outputs of similar age from Osteoporosis International
#8
of 59 outputs
Altmetric has tracked 25,874,560 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,888 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 91% of its peers.
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We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.