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Mendeley readers
Attention Score in Context
| Title |
A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, September 2002
|
| DOI | 10.1073/pnas.192172299 |
| Pubmed ID | |
| Authors |
Immaculata De Vivo, Gordon S. Huggins, Susan E. Hankinson, Pamela J. Lescault, Marike Boezen, Graham A. Colditz, David J. Hunter |
| Abstract |
Excessive estrogen stimulation unopposed by progesterone strongly predisposes to endometrial cancer. Because the antiproliferative effect of progesterone requires the progesterone receptor (PR), which exists in two isoforms, PR-A and -B, we reasoned that variants in the PR gene may predispose to endometrial cancer. We found six variable sites, including four polymorphisms in the hPR gene and five common haplotypes. One promoter region polymorphism, +331G/A, creates a unique transcription start site. Biochemical assays showed that the +331G/A polymorphism increases transcription of the PR gene, favoring production of hPR-B in an endometrial cancer cell line. Using a case-control study nested within the Nurses' Health Study cohort, we observed a statistically significant association between the +331G/A polymorphism and the risk of endometrial cancer, which was even greater in overweight women carriers. After including a second population of controls, these associations remained intact. Our findings suggest that the +331G/A hPR gene polymorphism may contribute to endometrial cancer risk by increasing expression of the hPR-B isoform. |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 6% |
| Unknown | 47 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 22% |
| Student > Ph. D. Student | 8 | 16% |
| Professor | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Professor > Associate Professor | 3 | 6% |
| Other | 9 | 18% |
| Unknown | 12 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 22% |
| Medicine and Dentistry | 10 | 20% |
| Biochemistry, Genetics and Molecular Biology | 6 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Mathematics | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 18 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2022.
All research outputs
#8,219,054
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#64,491
of 101,438 outputs
Outputs of similar age
#16,276
of 47,395 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#309
of 515 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 47,395 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 515 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.