| Title |
Characterization of a novel miniaturized burst-mode infrared laser system for IR-MALDESI mass spectrometry imaging
|
|---|---|
| Published in |
Analytical & Bioanalytical Chemistry, February 2018
|
| DOI | 10.1007/s00216-018-0918-9 |
| Pubmed ID | |
| Authors |
Måns Ekelöf, Jeffrey Manni, Milad Nazari, Mark Bokhart, David C. Muddiman |
| Abstract |
Laser systems are widely used in mass spectrometry as sample probes and ionization sources. Mid-infrared lasers are particularly suitable for analysis of high water content samples such as animal and plant tissues, using water as a resonantly excited sacrificial matrix. Commercially available mid-IR lasers have historically been bulky and expensive due to cooling requirements. This work presents a novel air-cooled miniature mid-IR laser with adjustable burst-mode output and details an evaluation of its performance for mass spectrometry imaging. The miniature laser was found capable of generating sufficient energy for complete ablation of animal tissue in the context of an IR-MALDESI experiment with exogenously added ice matrix, yielding several hundred confident metabolite identifications. Graphical abstract The use of a novel miniature 2.94 μm burst-mode laser in IR-MALDESI allows for rapid and sensitive mass spectrometry imaging of a whole mouse. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 25% |
| United Kingdom | 2 | 13% |
| France | 1 | 6% |
| Panama | 1 | 6% |
| Mexico | 1 | 6% |
| Unknown | 7 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 9 | 56% |
| Members of the public | 5 | 31% |
| Science communicators (journalists, bloggers, editors) | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 28% |
| Researcher | 7 | 24% |
| Student > Postgraduate | 2 | 7% |
| Other | 1 | 3% |
| Student > Doctoral Student | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 10 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 12 | 41% |
| Medicine and Dentistry | 2 | 7% |
| Physics and Astronomy | 2 | 7% |
| Agricultural and Biological Sciences | 1 | 3% |
| Computer Science | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 9 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2021.
All research outputs
#3,344,433
of 25,382,440 outputs
Outputs from Analytical & Bioanalytical Chemistry
#345
of 9,619 outputs
Outputs of similar age
#66,009
of 344,026 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#11
of 184 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,619 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,026 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 184 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.