| Title |
Mechanisms of postinhibitory rebound and its modulation by serotonin in excitatory swim motor neurons of the medicinal leech
|
|---|---|
| Published in |
Journal of Comparative Physiology A, April 2005
|
| DOI | 10.1007/s00359-005-0628-6 |
| Pubmed ID | |
| Authors |
James D. Angstadt, Jeffrey L. Grassmann, Kraig M. Theriault, Sarah M. Levasseur |
| Abstract |
Postinhibitory rebound (PIR) is defined as membrane depolarization occurring at the offset of a hyperpolarizing stimulus and is one of several intrinsic properties that may promote rhythmic electrical activity. PIR can be produced by several mechanisms including hyperpolarization-activated cation current (I(h)) or de-inactivation of depolarization-activated inward currents. Excitatory swim motor neurons in the leech exhibit PIR in response to injected current pulses or inhibitory synaptic input. Serotonin, a potent modulator of leech swimming behavior, increases the peak amplitude of PIR and decreases its duration, effects consistent with supporting rhythmic activity. In this study, we performed current clamp experiments on dorsal excitatory cell 3 (DE-3) and ventral excitatory cell 4 (VE-4). We found a significant difference in the shape of PIR responses expressed by these two cell types in normal saline, with DE-3 exhibiting a larger prolonged component. Exposing motor neurons to serotonin eliminated this difference. Cs+ had no effect on PIR, suggesting that I(h) plays no role. PIR was suppressed completely when low Na+ solution was combined with Ca2+-channel blockers. Our data support the hypothesis that PIR in swim motor neurons is produced by a combination of low-threshold Na+ and Ca2+ currents that begin to activate near -60 mV. |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Singapore | 1 | 2% |
| Unknown | 60 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 24% |
| Student > Ph. D. Student | 13 | 21% |
| Student > Bachelor | 12 | 19% |
| Researcher | 8 | 13% |
| Other | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 9 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 33% |
| Neuroscience | 15 | 24% |
| Medicine and Dentistry | 4 | 6% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Psychology | 2 | 3% |
| Other | 8 | 13% |
| Unknown | 9 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2011.
All research outputs
#7,856,604
of 23,815,455 outputs
Outputs from Journal of Comparative Physiology A
#468
of 1,450 outputs
Outputs of similar age
#20,901
of 59,060 outputs
Outputs of similar age from Journal of Comparative Physiology A
#5
of 11 outputs
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So far Altmetric has tracked 1,450 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
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