| Title |
Death Effector Domain-Containing Proteins
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, November 2008
|
| DOI | 10.1007/s00018-008-8489-0 |
| Pubmed ID | |
| Authors |
M. Gudur Valmiki, J. W. Ramos |
| Abstract |
Death effector domains (DEDs) are protein-protein interaction structures that are found in proteins that regulate a variety of signal transduction pathways. DEDs are a part of the larger family of Death Domain structures that have been primarily described in the control of programmed cell death. The seven standard DED-containing proteins are fas associated death domain protein (FADD), Caspase-8 and 10, cellular FLICE-like inhibitory protein (c-FLIP), death effector domain containing DNA binding (DEDD), DEDD2 and phosphoprotein enriched in astrocytes 15-Kda (PEA-15). These proteins are particularly associated with the regulation of apoptosis and proliferation mediated by the tumor necrosis factor alpha (TNFalpha) receptor family. Consequently DED-containing proteins are reported to regulate transcription, migration, and proliferation, in addition to both pro and anti-apoptotic functions. Moreover, DED proteins are essential in embryonic development and homeostasis of the immune system. Here we focus on the role of DED-containing proteins in development and the pathologies arising from abnormal expression of these proteins. |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Germany | 2 | 3% |
| United Kingdom | 1 | 1% |
| Unknown | 63 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 20% |
| Student > Ph. D. Student | 12 | 17% |
| Student > Bachelor | 9 | 13% |
| Student > Master | 7 | 10% |
| Professor > Associate Professor | 5 | 7% |
| Other | 15 | 22% |
| Unknown | 7 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 41% |
| Biochemistry, Genetics and Molecular Biology | 15 | 22% |
| Medicine and Dentistry | 9 | 13% |
| Neuroscience | 3 | 4% |
| Chemistry | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 8 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2019.
All research outputs
#4,965,094
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#928
of 4,151 outputs
Outputs of similar age
#18,062
of 93,842 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#8
of 42 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,842 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.