Title |
Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?
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Published in |
Applied Microbiology and Biotechnology, February 2018
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DOI | 10.1007/s00253-018-8811-1 |
Pubmed ID | |
Authors |
Barbara Maciejewska, Tomasz Olszak, Zuzanna Drulis-Kawa |
Abstract |
Bacteriophages (phages) are viruses that infect bacteria. The "predator-prey" interactions are recognized as a potentially effective way to treat infections. Phages, as well as phage-derived proteins, especially enzymes, are intensively studied to become future alternative or supportive antibacterials used alone or in combination with standard antibiotic regimens treatment. There are many publications presenting phage therapy aspects, and some papers focused separately on the application of phage-derived enzymes. In this review, we discuss advantages and limitations of both agents concerning their specificity, mode of action, structural issues, resistance development, pharmacokinetics, product preparation, and interactions with the immune system. Finally, we describe the current regulations for phage-based product application. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 377 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 63 | 17% |
Student > Ph. D. Student | 56 | 15% |
Student > Master | 50 | 13% |
Researcher | 34 | 9% |
Student > Postgraduate | 14 | 4% |
Other | 41 | 11% |
Unknown | 119 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 71 | 19% |
Immunology and Microbiology | 60 | 16% |
Agricultural and Biological Sciences | 46 | 12% |
Medicine and Dentistry | 22 | 6% |
Veterinary Science and Veterinary Medicine | 10 | 3% |
Other | 38 | 10% |
Unknown | 130 | 34% |