Title |
Marine ω-3 polyunsaturated fatty acid and fish intake after colon cancer diagnosis and survival: CALGB 89803 (Alliance)
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Published in |
Cancer Epidemiology, Biomarkers & Prevention, April 2018
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DOI | 10.1158/1055-9965.epi-17-0689 |
Pubmed ID | |
Authors |
Erin L Van Blarigan, Charles S Fuchs, Donna Niedzwiecki, Xing Ye, Sui Zhang, Mingyang Song, Leonard B Saltz, Robert J Mayer, Rex B Mowat, Renaud Whittom, Alexander Hantel, Al Benson, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Shuji Ogino, Edward L Giovannucci, Jeffrey A Meyerhardt |
Abstract |
Marine ω-3 polyunsaturated fatty acids (PUFAs), primarily found in dark fish, may prevent colorectal cancer progression, in part through inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2). However, data in humans are limited. We examined marine ω-3 PUFAs and fish intake and survival among 1,011 colon cancer patients enrolled in CALGB 89803 between 1999 to 2001 and followed through 2009. Diet was assessed during and 6 months after chemotherapy. We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI) for disease-free (DFS), recurrence-free (RFS), and overall survival (OS). We observed 343 recurrences and 305 deaths (median follow-up: 7 y). Patients in the highest vs. lowest quartile of marine ω-3 PUFA intake had a HR for DFS of 0.72 (95% CI: 0.54, 0.97; p-trend: 0.03). Individuals who consumed dark fish ≥1/week vs. never had longer DFS [HR: 0.65 (0.48, 0.87); p-value: 0.007], RFS [HR: 0.61 (0.46, 0.86); p-trend: 0.007], and OS [HR: 0.68 (0.48, 0.96); p-trend: 0.04]. In a subset of 510 patients, the association between marine ω-3 PUFA intake and DFS appeared stronger in patients with high PTGS2 expression [HR: 0.32 (0.11, 0.95); p-trend: 0.01] compared to patients with absent/low PTGS2 expression [HR: 0.78 (0.48, 1.27); p-trend: 0.35] (p-interaction: 0.19). Patients with high intake of marine ω-3 PUFAs and dark fish after colon cancer diagnosis may have longer DFS. Randomized controlled trials examining dark fish and/or marine ω-3 PUFA supplements and colon cancer recurrence/survival are needed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 20% |
France | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 76 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 13% |
Researcher | 8 | 11% |
Other | 6 | 8% |
Student > Bachelor | 6 | 8% |
Librarian | 3 | 4% |
Other | 15 | 20% |
Unknown | 28 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 21% |
Nursing and Health Professions | 7 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Immunology and Microbiology | 3 | 4% |
Engineering | 2 | 3% |
Other | 5 | 7% |
Unknown | 39 | 51% |