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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Establishment of the nasal microbiota in the first 18 months of life: Correlation with early-onset rhinitis and wheezing
|
|---|---|
| Published in |
The Journal of Allergy and Clinical Immunology, February 2018
|
| DOI | 10.1016/j.jaci.2018.01.032 |
| Pubmed ID | |
| Authors |
Le Duc Huy Ta, Gaik Chin Yap, Carina Jing Xuan Tay, Alicia Shi Min Lim, Chiung-Hui Huang, Collins Wenhan Chu, Paola Florez De Sessions, Lynette P Shek, Anne Goh, Hugo P S Van Bever, Oon Hoe Teoh, Jian Yi Soh, Biju Thomas, Mahesh Babu Ramamurthy, Daniel Y T Goh, Christophe Lay, Shu-E Soh, Yiong Huak Chan, Seang-Mei Saw, Kenneth Kwek, Yap-Seng Chong, Keith M Godfrey, Martin Lloyd Hibberd, Bee Wah Lee |
| Abstract |
The dynamic establishment of the nasal microbiota in early life influences local mucosal immune responses and the susceptibility to childhood respiratory disorders. The aim of this case-control study was to monitor, evaluate and compare the development of the nasal microbiota of infants who developed rhinitis and wheeze in the first 18 months of life with those of healthy controls. Anterior nasal swabs of 122 subjects belonging to the GUSTO birth cohort were collected longitudinally over seven time points in the first 18 months of life. The nasal microbiota signatures were analyzed using 16S rRNA multiplexed pair-end sequencing from three clinical groups (1) rhinitis alone (n=28), (2) rhinitis with concomitant wheeze (n=34) and (3) healthy controls (n=60). The maturation of the nasal microbiome followed distinctive patterns in infants from both rhinitis groups compared to controls. Bacterial diversity increased over the period of 18 months of life in control infants, whilst infants with rhinitis showed a decreasing trend (p<0.05). An increase in abundance of Oxalobacteraceae family (Proteobacteria phylum) and Aerococcaceae family (Firmicutes phylum) was associated with rhinitis and concomitant wheeze (adj p<0.01) whilst Corynebacteriaceae family (Actinobacteria phylum) and early colonization with Staphylococcaceae family (Firmicutes phylum) (3 weeks till 9 months) was associated with controls (adj p<0.05). The only difference between the rhinitis group and controls was a reduced abundance of Corynebacteriaceae family (adj p<0.05). Determinants of nasal microbiota succession included gender, mode of delivery, presence of siblings and infant care attendance. Our results support the hypothesis that nasal microbiome is involved in the development of early onset rhinitis and wheeze in infants. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 14% |
| France | 2 | 9% |
| United States | 2 | 9% |
| Spain | 2 | 9% |
| El Salvador | 1 | 5% |
| Australia | 1 | 5% |
| Ecuador | 1 | 5% |
| Mexico | 1 | 5% |
| Unknown | 9 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 64% |
| Practitioners (doctors, other healthcare professionals) | 6 | 27% |
| Scientists | 1 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 130 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 15% |
| Researcher | 18 | 14% |
| Student > Master | 13 | 10% |
| Student > Bachelor | 11 | 8% |
| Other | 9 | 7% |
| Other | 24 | 18% |
| Unknown | 36 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 25% |
| Immunology and Microbiology | 13 | 10% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Nursing and Health Professions | 9 | 7% |
| Agricultural and Biological Sciences | 9 | 7% |
| Other | 18 | 14% |
| Unknown | 38 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2019.
All research outputs
#1,849,192
of 25,411,814 outputs
Outputs from The Journal of Allergy and Clinical Immunology
#1,528
of 11,258 outputs
Outputs of similar age
#44,050
of 455,412 outputs
Outputs of similar age from The Journal of Allergy and Clinical Immunology
#62
of 205 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,258 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 455,412 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 205 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.