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6q deletion discriminates Waldenström macroglobulinemia from IgM monoclonal gammopathy of undetermined significance

Overview of attention for article published in Cancer Genetics, September 2006
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Title
6q deletion discriminates Waldenström macroglobulinemia from IgM monoclonal gammopathy of undetermined significance
Published in
Cancer Genetics, September 2006
DOI 10.1016/j.cancergencyto.2006.04.009
Pubmed ID
Authors

Roelandt F.J. Schop, Scott A. Van Wier, Ruifang Xu, Irene Ghobrial, Gregory J. Ahmann, Philip R. Greipp, Robert A. Kyle, Angela Dispenzieri, Martha Q. Lacy, S. Vincent Rajkumar, Morie A. Gertz, Rafael Fonseca

Abstract

IgM monoclonal gammopathy of undetermined significance (IgM MGUS) and Waldenström macroglobulinemia (WM) are sometimes clinically difficult to distinguish. In our previous study, deletion of the long arm of chromosome 6 (6q) was found in about half of WM patients. To further clarify the area of minimal deletion at 6q (6q-) and to address the issue of whether 6q- occurs in IgM MGUS, 12 IgM MGUS and 38 WM patients were studied by fluorescence in situ hybridization using probes targeting different chromosomal segments of 6q. No 6q deletions were found in IgM MGUS samples. Of 38 successfully studied WM patients, 21 (55%) showed a deletion of 6q. The area of minimal deletion was between 6q23 and 6q24.3, but the deletion usually encompassed a large fragment of the 6q arm. These results indicate that 6q- can distinguish WM from IgM MGUS and is likely to be a secondary event.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 20%
Student > Ph. D. Student 3 15%
Other 2 10%
Student > Master 2 10%
Lecturer 2 10%
Other 2 10%
Unknown 5 25%
Readers by discipline Count As %
Medicine and Dentistry 10 50%
Biochemistry, Genetics and Molecular Biology 2 10%
Agricultural and Biological Sciences 1 5%
Unknown 7 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2011.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from Cancer Genetics
#241
of 1,174 outputs
Outputs of similar age
#30,678
of 89,592 outputs
Outputs of similar age from Cancer Genetics
#3
of 9 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,174 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
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We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.