| Title |
Expression, regulation and function of human FcεRII (CD23) antigen
|
|---|---|
| Published in |
Immunologic Research, December 1992
|
| DOI | 10.1007/bf02919132 |
| Pubmed ID | |
| Authors |
M. Sarfati, S. Fournier, C. Y. Wu, G. Delespesse |
| Abstract |
CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by several cytokines (i.e., interleukin-4, interferons) in a tissue-specific manner. In some pathological conditions such as B-chronic lymphocytic leukemia, the CD23 gene is abnormally regulated resulting in CD23 overexpression. CD23 is not only an IgE receptor but also a membrane-bound precursor of soluble molecules that still bind IgE (sCD23 or IgE-binding factors). The functions of membrane CD23 are IgE-dependent and vary according to the cell types on which it is expressed. In contrast, sCD23, in addition to being an IgE regulatory molecule, displays multiple cytokine activities that are IgE-independent. |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 23% |
| Researcher | 2 | 15% |
| Professor | 2 | 15% |
| Student > Doctoral Student | 1 | 8% |
| Student > Master | 1 | 8% |
| Other | 2 | 15% |
| Unknown | 2 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 4 | 31% |
| Agricultural and Biological Sciences | 3 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
| Biochemistry, Genetics and Molecular Biology | 1 | 8% |
| Medicine and Dentistry | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 2 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2022.
All research outputs
#7,633,928
of 23,257,423 outputs
Outputs from Immunologic Research
#282
of 914 outputs
Outputs of similar age
#13,128
of 65,661 outputs
Outputs of similar age from Immunologic Research
#1
of 5 outputs
Altmetric has tracked 23,257,423 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 914 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
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