| Title |
Acute exposure to copper induces variable intensity of oxidative stress in goldfish tissues
|
|---|---|
| Published in |
Fish Physiology and Biochemistry, February 2018
|
| DOI | 10.1007/s10695-018-0473-5 |
| Pubmed ID | |
| Authors |
Viktor V. Husak, Nadia M. Mosiichuk, Olga I. Kubrak, Tetiana M. Matviishyn, Janet M. Storey, Kenneth B. Storey, Volodymyr I. Lushchak |
| Abstract |
Copper is an essential element, but at high concentrations, it is toxic for living organisms. The present study investigated the responses of goldfish, Carassius auratus, to 96 h exposure to 30, 300, or 700 μg L-1of copper II chloride (Cu2+). The content of protein carbonyls was higher in kidney (by 158%) after exposure to 700 mg L-1copper, whereas in gills, liver, and brain, we observed lower content of protein carbonyls after exposure to copper compared with control values. Exposure to copper resulted in increased levels of lipid peroxides in gills (76%) and liver (95-110%) after exposure to 300 and 700 μg L-1Cu2+. Low molecular mass thiols were depleted by 23-40% in liver and by 29-67% in kidney in response to copper treatment and can be used as biomarkers toxicity of copper. The activities of primary antioxidant enzymes, superoxide dismutase and catalase, were increased in liver as a result of Cu2+exposure, whereas in kidney catalase activity was decreased. The activities of glutathione-related enzymes, glutathione peroxidase, glutathione-S-transferase, and glutathione reductase were decreased as a result of copper exposure, but glutathione reductase activity increased by 25-40% in liver. Taken together, these data show that exposure of fish to Cu2+ions results in the development of low/high intensity oxidative stress reflected in enhanced activities of antioxidant and associated enzymes in different goldfish tissues. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 20% |
| Student > Doctoral Student | 3 | 12% |
| Student > Master | 2 | 8% |
| Lecturer | 1 | 4% |
| Librarian | 1 | 4% |
| Other | 4 | 16% |
| Unknown | 9 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 12% |
| Agricultural and Biological Sciences | 3 | 12% |
| Medicine and Dentistry | 2 | 8% |
| Environmental Science | 2 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 13 | 52% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2018.
All research outputs
#20,465,050
of 23,023,224 outputs
Outputs from Fish Physiology and Biochemistry
#608
of 867 outputs
Outputs of similar age
#292,574
of 331,055 outputs
Outputs of similar age from Fish Physiology and Biochemistry
#14
of 36 outputs
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