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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia
|
|---|---|
| Published in |
Nature Communications, February 2018
|
| DOI | 10.1038/s41467-018-03170-7 |
| Pubmed ID | |
| Authors |
Carmen D. Herling, Nima Abedpour, Jonathan Weiss, Anna Schmitt, Ron Daniel Jachimowicz, Olaf Merkel, Maria Cartolano, Sebastian Oberbeck, Petra Mayer, Valeska Berg, Daniel Thomalla, Nadine Kutsch, Marius Stiefelhagen, Paula Cramer, Clemens-Martin Wendtner, Thorsten Persigehl, Andreas Saleh, Janine Altmüller, Peter Nürnberg, Christian Pallasch, Viktor Achter, Ulrich Lang, Barbara Eichhorst, Roberta Castiglione, Stephan C. Schäfer, Reinhard Büttner, Karl-Anton Kreuzer, Hans Christian Reinhardt, Michael Hallek, Lukas P. Frenzel, Martin Peifer |
| Abstract |
Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance. To this end, we analyzed whole-exome sequencing data of eight chronic lymphocytic leukemia (CLL) patients that developed resistance upon BCL2-inhibition by venetoclax. Here, we report recurrent mutations in BTG1 (2 patients) and homozygous deletions affecting CDKN2A/B (3 patients) that developed during treatment, as well as a mutation in BRAF and a high-level focal amplification of CD274 (PD-L1) that might pinpoint molecular aberrations offering structures for further therapeutic interventions. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 25% |
| France | 2 | 17% |
| Unknown | 7 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 42% |
| Scientists | 5 | 42% |
| Science communicators (journalists, bloggers, editors) | 2 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 168 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 168 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 17% |
| Researcher | 28 | 17% |
| Student > Master | 11 | 7% |
| Student > Doctoral Student | 8 | 5% |
| Other | 8 | 5% |
| Other | 28 | 17% |
| Unknown | 57 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 37 | 22% |
| Biochemistry, Genetics and Molecular Biology | 34 | 20% |
| Agricultural and Biological Sciences | 16 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Immunology and Microbiology | 5 | 3% |
| Other | 12 | 7% |
| Unknown | 58 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2021.
All research outputs
#4,836,497
of 23,577,761 outputs
Outputs from Nature Communications
#33,673
of 49,102 outputs
Outputs of similar age
#91,925
of 332,326 outputs
Outputs of similar age from Nature Communications
#850
of 1,186 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 49,102 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,326 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 1,186 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.