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Expression of MAGE‐A and NY‐ESO‐1 cancer/testis antigens is enriched in triple‐negative invasive breast cancers

Overview of attention for article published in Histopathology, April 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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1 news outlet
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Title
Expression of MAGE‐A and NY‐ESO‐1 cancer/testis antigens is enriched in triple‐negative invasive breast cancers
Published in
Histopathology, April 2018
DOI 10.1111/his.13498
Pubmed ID
Authors

Ashwini Raghavendra, Priyakshi Kalita‐de Croft, Ana C Vargas, Chanel E Smart, Peter T Simpson, Jodi M Saunus, Sunil R Lakhani

Abstract

A better understanding of the expression of cancer testis antigens (CTA) in breast cancer might identify new immunotherapy options, especially for triple-negative (TN) tumours, which lack expression of conventional therapeutic targets ER, PR and HER2 (receptors for Oestrogen, Progesterone and Human epidermal growth factor). The aim of this study was to quantify the expression of MAGE-A and NY-ESO-1 CTAs in breast cancer, and relate this to known clinicopathologic parameters. We surveyed MAGE-A and NY-ESO-1 protein expression in an unselected cohort of 367 breast tumours (out of which 65 tumours were TN), with accompanying clinical follow-up data, using immunohistochemistry (IHC) analysis of tissue microarrays. Relevant to their potential as vaccine targets in breast cancer, MAGE-A was expressed in 13% of cases, and NY-ESO-1 in 3.8%, with the majority of tumours exhibiting fairly homogeneous staining within individual tissue cores (~85% of cases with staining in >75% tumour cells). Most NY-ESO-1 positive cases also expressed MAGE-A (p=2.06x10-9), and both were strongly associated with the TN phenotype (p<0.0001); particularly the most proliferative and poorly differentiated cases displaying genomic instabililty. This was characterised by co-expression of c-kit, TTK and overexpression of p53. MAGE-A and NY-ESO-1 are frequently expressed in TNBC (~47% and 17% of TN cases, respectively), suggesting that targeting them could be feasible in this patient group. Expression is reasonably homogeneous in positive cases suggesting that IHC analysis of tissue biopsies would be a reliable companion biomarker. This article is protected by copyright. All rights reserved.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 14%
Student > Ph. D. Student 5 12%
Student > Master 3 7%
Librarian 2 5%
Researcher 2 5%
Other 8 19%
Unknown 16 38%
Readers by discipline Count As %
Medicine and Dentistry 9 21%
Biochemistry, Genetics and Molecular Biology 7 17%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Chemistry 2 5%
Social Sciences 1 2%
Other 3 7%
Unknown 17 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2023.
All research outputs
#3,167,266
of 24,795,084 outputs
Outputs from Histopathology
#307
of 3,445 outputs
Outputs of similar age
#62,512
of 332,999 outputs
Outputs of similar age from Histopathology
#6
of 59 outputs
Altmetric has tracked 24,795,084 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,445 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,999 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.