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Attention Score in Context
| Title |
A biodegradable porous composite scaffold of PGA/β-TCP for bone tissue engineering
|
|---|---|
| Published in |
BONE, September 2009
|
| DOI | 10.1016/j.bone.2009.09.031 |
| Pubmed ID | |
| Authors |
Hong Cao, Noboru Kuboyama |
| Abstract |
Polyglycolic acid (PGA) and beta-tricalcium phosphate (beta-TCP) each have many applications as tissue repair materials. In this study, three-dimensional (3D) porous composite scaffolds of PGA/beta-TCP (in 1:1 and 1:3 weight ratios) were fabricated using the solvent casting and particulate leaching method. PGA/beta-TCP scaffolds with high porosity, interconnected 3D pores and rough surfaces were obtained and were observed using scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). The PGA/beta-TCP scaffolds were investigated during the repair of critical bone defects (3 mm diameter, 2 mm depth) in rat femoral medial-epicondyles, compared with hydroxylapatite (HAP) and no implant as controls. Quantitative imageology analysis (volume and density of new bone) and qualitative histological evaluations (hematoxylin and eosin staining; tartrate-resistant acid phosphatase-hematoxylin counterstaining) were characterized using in vivo micro-CT images and histological sections at 0, 14, 30 and 90 days after surgery. Significant differences of all variables were tested by multivariate analysis (p<0.05). The results showed that the bone reformation by using the PGA/beta-TCP scaffolds began within 14 days of surgery, and were healing well at 30 days after surgery. By 90 days after surgery, the bone replacement was almost completed and presented a healthy bone appearance. The new bone mineral densities (mg/cm(3)) with HAP, PGA/beta-TCP (1:1) and PGA/beta-TCP (1:3) at 90 days after surgery were: 390.4+/-18.1, 563.8+/-26.9 and 606.3+/-26.9, respectively. The new bone mineral density with the PGA/beta-TCP scaffold was higher than with HAP (p<0.001), and with the PGA/beta-TCP (1:3) scaffold was higher than with the PGA/beta-TCP (1:1) scaffold at each time examined (p<0.05). The biodegradation percents (%) of HAP, PGA/beta-TCP (1:1) and PGA/beta-TCP (1:3) at 90 days after surgery were: 35.1+/-5.5, 99.0+/-1.0 and 96.2+/-3.3, respectively. The biodegradation percents of the PGA/beta-TCP scaffolds were higher than HAP at each time examined (p<0.01), and matched the osteogenesis rates. The PGA/beta-TCP scaffolds were almost replaced by new growing bone within 90 days after surgery. Thus the PGA/beta-TCP composite scaffold, especially weight ratio 1:3, exhibited a strong ability for osteogenesis, mineralization and biodegradation for bone replacement. |
Mendeley readers
The data shown below were compiled from readership statistics for 303 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Turkey | 1 | <1% |
| Ireland | 1 | <1% |
| United Kingdom | 1 | <1% |
| Taiwan | 1 | <1% |
| Russia | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 296 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 57 | 19% |
| Student > Master | 54 | 18% |
| Student > Bachelor | 39 | 13% |
| Researcher | 29 | 10% |
| Student > Doctoral Student | 20 | 7% |
| Other | 38 | 13% |
| Unknown | 66 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 65 | 21% |
| Materials Science | 47 | 16% |
| Agricultural and Biological Sciences | 28 | 9% |
| Medicine and Dentistry | 26 | 9% |
| Biochemistry, Genetics and Molecular Biology | 18 | 6% |
| Other | 37 | 12% |
| Unknown | 82 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2022.
All research outputs
#8,543,833
of 25,394,764 outputs
Outputs from BONE
#1,269
of 4,330 outputs
Outputs of similar age
#37,589
of 106,300 outputs
Outputs of similar age from BONE
#8
of 22 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,330 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,300 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.