| Title |
Canonical TRP channels and mechanotransduction: from physiology to disease states
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, May 2010
|
| DOI | 10.1007/s00424-010-0847-8 |
| Pubmed ID | |
| Authors |
Amanda Patel, Reza Sharif-Naeini, Joost R. H. Folgering, Delphine Bichet, Fabrice Duprat, Eric Honoré |
| Abstract |
Mechano-gated ion channels play a key physiological role in cardiac, arterial, and skeletal myocytes. For instance, opening of the non-selective stretch-activated cation channels in smooth muscle cells is involved in the pressure-dependent myogenic constriction of resistance arteries. These channels are also implicated in major pathologies, including cardiac hypertrophy or Duchenne muscular dystrophy. Seminal work in prokaryotes and invertebrates highlighted the role of transient receptor potential (TRP) channels in mechanosensory transduction. In mammals, recent findings have shown that the canonical TRPC1 and TRPC6 channels are key players in muscle mechanotransduction. In the present review, we will focus on the functional properties of TRPC1 and TRPC6 channels, on their mechano-gating, regulation by interacting cytoskeletal and scaffolding proteins, physiological role and implication in associated diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| France | 2 | 2% |
| Switzerland | 1 | <1% |
| Portugal | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Sweden | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 109 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 23% |
| Student > Ph. D. Student | 23 | 19% |
| Professor | 11 | 9% |
| Professor > Associate Professor | 10 | 8% |
| Student > Bachelor | 10 | 8% |
| Other | 22 | 18% |
| Unknown | 17 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 43% |
| Medicine and Dentistry | 17 | 14% |
| Biochemistry, Genetics and Molecular Biology | 11 | 9% |
| Engineering | 5 | 4% |
| Neuroscience | 3 | 3% |
| Other | 11 | 9% |
| Unknown | 21 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2021.
All research outputs
#7,856,604
of 23,818,521 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#476
of 1,973 outputs
Outputs of similar age
#34,714
of 96,525 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#4
of 7 outputs
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So far Altmetric has tracked 1,973 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
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We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.