| Title |
Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) - study protocol for a randomized controlled trial
|
|---|---|
| Published in |
Trials, June 2014
|
| DOI | 10.1186/1745-6215-15-204 |
| Pubmed ID | |
| Authors |
Vladimir J Lozanovski, Philipp Houben, Ulf Hinz, Thilo Hackert, Ingrid Herr, Peter Schemmer |
| Abstract |
Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive malignancies with marked resistance to chemo- and radiotherapy. PDA-cancer stem cells (CSCs) are not targeted by current therapies and may be a reason for poor prognosis. Studies indicate that diets rich in cabbage, broccoli, and cauliflower offer cancer preventative and therapeutic benefits. Recent experimental studies have confirmed these findings and demonstrated that isothiocyanate, sulforaphane, and the polyphenol, quercetin, effectively reduced tumor growth and enhanced the sensitivity of the cancer cells to current chemotherapeutics. The aim of the present study is to test the feasibility of a randomized controlled trial on the application of freeze-dried broccoli sprouts in patients with advanced PDA. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mauritius | 1 | <1% |
| Unknown | 126 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 13% |
| Student > Bachelor | 16 | 13% |
| Student > Master | 13 | 10% |
| Student > Doctoral Student | 11 | 9% |
| Student > Ph. D. Student | 9 | 7% |
| Other | 24 | 19% |
| Unknown | 37 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 25% |
| Agricultural and Biological Sciences | 12 | 9% |
| Biochemistry, Genetics and Molecular Biology | 10 | 8% |
| Nursing and Health Professions | 9 | 7% |
| Psychology | 8 | 6% |
| Other | 12 | 9% |
| Unknown | 44 | 35% |