| Title |
The Nijmegen breakage syndrome gene and its role in genome stability
|
|---|---|
| Published in |
Chromosoma, July 2004
|
| DOI | 10.1007/s00412-004-0298-0 |
| Pubmed ID | |
| Authors |
Kenta Iijima, Kenshi Komatsu, Shinya Matsuura, Hiroshi Tauchi |
| Abstract |
NBS1 is the key regulator of the RAD50/MRE11/NBS1 (R/M/N) protein complex, a sensor and mediator for cellular DNA damage response. NBS1 potentiates the enzymatic activity of MRE11 and directs the R/M/N complex to sites of DNA damage, where it forms nuclear foci by interacting with phosphorylated H2AX. The R/M/N complex also activates the ATM kinase, which is a major kinase involved in the activation of DNA damage signal pathways. The ATM requires the R/M/N complex for its own activation following DNA damage, and for conformational change to develop a high affinity for target proteins. In addition, association of NBS1 with PML, the promyelocytic leukemia protein, is required to form nuclear bodies, which have various functions depending on their location and composition. These nuclear bodies function not only in response to DNA damage, but are also involved in telomere maintenance when they are located on telomeres. In this review, we describe the role of NBS1 in the maintenance of genetic stability through the activation of cell-cycle checkpoints, DNA repair, and protein relocation. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 5% |
| Austria | 1 | 5% |
| Unknown | 19 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 33% |
| Professor | 3 | 14% |
| Student > Ph. D. Student | 3 | 14% |
| Student > Master | 3 | 14% |
| Student > Doctoral Student | 2 | 10% |
| Other | 0 | 0% |
| Unknown | 3 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 52% |
| Medicine and Dentistry | 3 | 14% |
| Chemistry | 2 | 10% |
| Computer Science | 1 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 3 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2023.
All research outputs
#7,453,350
of 22,786,087 outputs
Outputs from Chromosoma
#178
of 757 outputs
Outputs of similar age
#14,446
of 41,332 outputs
Outputs of similar age from Chromosoma
#2
of 8 outputs
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So far Altmetric has tracked 757 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
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