| Title |
Ghrelin and Obestatin Levels in Type 2 Diabetic Patients With and Without Delayed Gastric Emptying
|
|---|---|
| Published in |
Digestive Diseases and Sciences, December 2008
|
| DOI | 10.1007/s10620-008-0622-2 |
| Pubmed ID | |
| Authors |
Igor A. Harsch, Corinna Koebnick, Atingwa M. Tasi, Eckhart Georg Hahn, Peter C. Konturek |
| Abstract |
Alterations in the neurohumoral regulation of the upper intestine may change rhythmicity and pattern of ghrelin and obestatin, the latter presumably antagonizing ghrelin effects. Five nongastroparetic diabetic patients and five with gastroparesis were investigated. Over 390 min including breakfast and lunch, ghrelin was significantly lower in patients with gastroparesis compared with in those without (P = 0.015). Ghrelin subsequent to lunch decreased significantly (P = 0.011) in patients without gastroparesis, but not in gastroparetic patients (P = 0.669). Obestatin was similar in both groups and unchanged. No significant differences in ghrelin-to-obestatin ratio were observed (P = 0.530). Loss of rhythmicity in the ghrelin levels of gastroparetic diabetics highlights the importance of integrity of the neurohumoral-intestinal axis. Stable diurnal obestatin levels do not support the concept of interaction between ghrelin and obestatin in terms of regulation of food intake and gastric emptying. |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 5% |
| Unknown | 18 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 21% |
| Student > Master | 3 | 16% |
| Student > Postgraduate | 2 | 11% |
| Researcher | 2 | 11% |
| Student > Doctoral Student | 1 | 5% |
| Other | 4 | 21% |
| Unknown | 3 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 26% |
| Medicine and Dentistry | 5 | 26% |
| Biochemistry, Genetics and Molecular Biology | 3 | 16% |
| Nursing and Health Professions | 1 | 5% |
| Neuroscience | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 4 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2019.
All research outputs
#7,917,073
of 23,854,458 outputs
Outputs from Digestive Diseases and Sciences
#1,379
of 4,304 outputs
Outputs of similar age
#49,078
of 170,055 outputs
Outputs of similar age from Digestive Diseases and Sciences
#20
of 39 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
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