| Title |
Epigenetic regulation of hematopoiesis
|
|---|---|
| Published in |
International Journal of Hematology, September 2012
|
| DOI | 10.1007/s12185-012-1183-x |
| Pubmed ID | |
| Authors |
Goro Sashida, Atsushi Iwama |
| Abstract |
Epigenetic regulation is required not only for development, but also for tissue homeostasis, which is maintained via the self-renewal and differentiation of somatic stem cells. Accumulating evidence suggests that epigenetic regulators play critical roles in the maintenance of both self-renewing hematopoietic stem cells and leukemic stem cells. Recent genome-wide comprehensive analyses have identified mutations in epigenetic regulator genes, including genes whose products modify DNA and histones in hematological malignancies. Among these epigenetic regulators, repressive histone modifications by Polycomb-group complexes have been most fully characterized in hematopoietic stem cells, and are recognized as general regulators of stem cells. Hematopoietic stem cells are controlled by both cell-intrinsic and -extrinsic regulators, including transcription factors, signal transduction pathways, and niche factors. However, there is little insight into the mechanism of how epigenetic regulators act in concert with these factors to ensure blood homeostasis. In this review, we highlight recent findings in epigenetic regulation of hematopoiesis with emphasis on the role of Polycomb-group proteins and DNA-methylation modulators in hematopoietic stem cells and their progeny. |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Czechia | 1 | <1% |
| Unknown | 106 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 27% |
| Researcher | 23 | 21% |
| Student > Bachelor | 12 | 11% |
| Student > Master | 9 | 8% |
| Student > Doctoral Student | 7 | 6% |
| Other | 13 | 12% |
| Unknown | 15 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 31% |
| Biochemistry, Genetics and Molecular Biology | 33 | 31% |
| Medicine and Dentistry | 15 | 14% |
| Immunology and Microbiology | 4 | 4% |
| Business, Management and Accounting | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 16 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2024.
All research outputs
#7,453,350
of 22,786,087 outputs
Outputs from International Journal of Hematology
#253
of 1,392 outputs
Outputs of similar age
#56,589
of 172,192 outputs
Outputs of similar age from International Journal of Hematology
#5
of 17 outputs
Altmetric has tracked 22,786,087 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,392 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 62% of its peers.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.