| Title |
Developmental Toxicity of Diethylnitrosamine in Zebrafish Embryos/Juveniles Related to Excessive Oxidative Stress
|
|---|---|
| Published in |
Water, Air, & Soil Pollution, February 2018
|
| DOI | 10.1007/s11270-018-3739-8 |
| Pubmed ID | |
| Authors |
Danping Huang, Hanmin Li, Qidi He, Weiqu Yuan, Zuanguang Chen, Hongzhi Yang |
| Abstract |
Diethylnitrosamine (DEN) is present in food, water, and daily supplies and is regarded as a toxicant of carcinogenicity. The developmental toxicity of DEN has been rarely reported as yet. In this study, zebrafish were exposed to different concentrations of DEN at 6 h post-fertilization (hpf) to access embryonic toxicity of the compound. The results show that DEN resulted in negative effects of hatching rate, heartbeat, body length, and spontaneous movement. Deformities, including notochord malformation, pericardium edema, embryonic membrane turbidity, tail hypoplasia, yolk sac deformity, and growth retardation, happened during exposure period. Moreover, production of reactive oxygen species (ROS) significantly increased after DEN treatment. Then, alterations of the expression level of oxidative stress-related genes were observed in our results. To our knowledge, this is the first study concerning the effect of DEN on zebrafish. And from the information of our research, we speculated that development toxicity of DEN should be related to the excessive oxidative stress. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 14% |
| Student > Master | 9 | 14% |
| Student > Bachelor | 9 | 14% |
| Student > Doctoral Student | 5 | 8% |
| Lecturer | 4 | 6% |
| Other | 9 | 14% |
| Unknown | 19 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 11% |
| Medicine and Dentistry | 6 | 9% |
| Agricultural and Biological Sciences | 4 | 6% |
| Environmental Science | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 22 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2018.
All research outputs
#19,443,721
of 23,914,147 outputs
Outputs from Water, Air, & Soil Pollution
#1,375
of 1,990 outputs
Outputs of similar age
#261,537
of 334,166 outputs
Outputs of similar age from Water, Air, & Soil Pollution
#20
of 58 outputs
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We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.