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Mendeley readers
Attention Score in Context
| Title |
Complement component 5a (C5a)
|
|---|---|
| Published in |
International Journal of Biochemistry & Cell Biology, April 2009
|
| DOI | 10.1016/j.biocel.2009.04.005 |
| Pubmed ID | |
| Authors |
Helga D. Manthey, Trent M. Woodruff, Stephen M. Taylor, Peter N. Monk |
| Abstract |
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert a number of effects essential to the innate immune response, while their actions at the more recently discovered non-G protein-coupled receptor, C5L2 (or GPR77), remain unclear. The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases, making C5a inhibition an attractive therapeutic strategy. |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 151 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 16% |
| Student > Bachelor | 25 | 16% |
| Student > Ph. D. Student | 23 | 15% |
| Student > Master | 17 | 11% |
| Student > Doctoral Student | 11 | 7% |
| Other | 22 | 14% |
| Unknown | 30 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 22% |
| Medicine and Dentistry | 29 | 19% |
| Biochemistry, Genetics and Molecular Biology | 25 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 8% |
| Immunology and Microbiology | 7 | 5% |
| Other | 14 | 9% |
| Unknown | 33 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2023.
All research outputs
#2,202,138
of 25,374,647 outputs
Outputs from International Journal of Biochemistry & Cell Biology
#74
of 2,858 outputs
Outputs of similar age
#6,609
of 106,739 outputs
Outputs of similar age from International Journal of Biochemistry & Cell Biology
#2
of 24 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,858 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,739 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.