Title |
The Met tyrosine kinase receptor in development and cancer
|
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Published in |
Cancer and Metastasis Reviews, January 2008
|
DOI | 10.1007/s10555-007-9107-6 |
Pubmed ID | |
Authors |
Alessandra Gentile, Livio Trusolino, Paolo M. Comoglio |
Abstract |
Met is a tyrosine kinase receptor, encoded by an oncogene, whose crucial role has been elucidated during the last two decades. The complex biological program triggered by Met has been dissected and its biological relevance in both physiology and pathology has been proven. Met supports a morphogenetic program, known as invasive growth, taking place both during embryogenesis and adulthood. In tumors Met is often aberrantly activated, giving rise to the pathological counterpart of the invasive growth program: cancer progression towards metastasis. Several approaches have been recently developed to interfere with the tumorigenic and metastatic processes triggered by Met. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | <1% |
United States | 1 | <1% |
Austria | 1 | <1% |
Australia | 1 | <1% |
Unknown | 141 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 21% |
Researcher | 25 | 17% |
Student > Master | 23 | 16% |
Student > Bachelor | 15 | 10% |
Professor > Associate Professor | 8 | 6% |
Other | 18 | 12% |
Unknown | 25 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 47 | 32% |
Medicine and Dentistry | 26 | 18% |
Biochemistry, Genetics and Molecular Biology | 25 | 17% |
Chemistry | 10 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 8 | 6% |
Unknown | 26 | 18% |