| Title |
P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis
|
|---|---|
| Published in |
Archivum Immunologiae et Therapiae Experimentalis, March 2006
|
| DOI | 10.1007/s00005-006-0010-6 |
| Pubmed ID | |
| Authors |
Ming Chen, Jian-Guo Geng |
| Abstract |
Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. Cross-linking of PSGL-1 by P-selectin also primes leukocytes intracellularly for cytokine and chemoattractant-induced beta2-integrin activation for firm adhesion of leukocytes. Furthermore, P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. Here we provide a comprehensive summary of the functional roles and the biological importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, and the growth and metastasis of cancers. |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 3 | 2% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| Russia | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 133 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 18% |
| Student > Master | 20 | 14% |
| Researcher | 18 | 13% |
| Student > Bachelor | 14 | 10% |
| Student > Doctoral Student | 9 | 6% |
| Other | 16 | 11% |
| Unknown | 38 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 19% |
| Medicine and Dentistry | 26 | 19% |
| Agricultural and Biological Sciences | 19 | 14% |
| Engineering | 10 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 14 | 10% |
| Unknown | 42 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2024.
All research outputs
#4,886,859
of 23,509,253 outputs
Outputs from Archivum Immunologiae et Therapiae Experimentalis
#57
of 393 outputs
Outputs of similar age
#12,537
of 67,484 outputs
Outputs of similar age from Archivum Immunologiae et Therapiae Experimentalis
#2
of 6 outputs
Altmetric has tracked 23,509,253 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 393 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,484 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.