| Title |
Immunophilins: for the love of proteins
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2006
|
| DOI | 10.1007/s00018-006-6215-3 |
| Pubmed ID | |
| Authors |
S. Barik |
| Abstract |
Immunophilins are chaperones that may also exhibit peptidylprolyl isomerase (PPIase) activity. This review summarizes our knowledge of the two largest families of immunophilins, namely cyclophilin and FK506-binding protein, and a novel chimeric dual-family immunophilin, named FK506- and cyclosporin-binding protein (FCBP). The larger members of each family are modular in nature, consisting of multiple PPIase and/or protein-protein interaction domains. Despite the apparent difference in their sequence and three-dimensional structure, the three families encode similar enzymatic and biological functions. Recent studies have revealed that many immunophilins possess a chaperone function independent of PPIase activity. Knockout animal studies have confirmed multiple essential roles of immunophilins in physiology and development. An immunophilin is indeed a natural 'protein-philin' (Greek 'philin' = friend) that interacts with proteins to guide their proper folding and assembly. |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| United Kingdom | 2 | 2% |
| Ireland | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 123 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 26% |
| Researcher | 19 | 15% |
| Student > Master | 16 | 12% |
| Student > Bachelor | 14 | 11% |
| Student > Doctoral Student | 9 | 7% |
| Other | 18 | 14% |
| Unknown | 20 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 49 | 38% |
| Biochemistry, Genetics and Molecular Biology | 30 | 23% |
| Medicine and Dentistry | 10 | 8% |
| Immunology and Microbiology | 7 | 5% |
| Chemistry | 5 | 4% |
| Other | 9 | 7% |
| Unknown | 20 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2021.
All research outputs
#3,460,684
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#571
of 4,151 outputs
Outputs of similar age
#7,781
of 70,239 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#4
of 32 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,239 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.