| Title |
Type 2 Diabetes Mellitus and Alzheimer’s Disease: Overlapping Biologic Mechanisms and Environmental Risk Factors
|
|---|---|
| Published in |
Current Environmental Health Reports, February 2018
|
| DOI | 10.1007/s40572-018-0176-1 |
| Pubmed ID | |
| Authors |
Kimberly C. Paul, Michael Jerrett, Beate Ritz |
| Abstract |
A number of studies over the past two decades have suggested that type 2 diabetes mellitus (T2DM) patients are at an increased risk of Alzheimer's disease (AD). Several common molecular pathways to cellular and metabolic dysfunction have been implicated in the etiology of both diseases. Here, we review the emerging evidence from observational studies that investigate the relationship between T2DM and AD, and of shared environmental risk factors, specifically air pollution and pesticides, associated with both chronic disorders. Particulate matter and traffic-related air pollution have been widely associated with T2DM, and multiple studies have associated exposures with AD or cognitive function. Organochlorine (OC) and organophosphate (OP) pesticides have been associated with T2DM in multiple independent populations. Two populations have observed increased risks for OC and OP exposures and AD. Other studies, limited in exposure assessment, have reported increased risk of AD with any pesticide exposure assessments. This may suggest shared pathogenic pathways between environmental risk factors, T2DM, and AD. Research focusing on exposures related to both T2DM and AD could provide new disease insights on shared mechanisms and help shape innovative preventative measures and policy decisions. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 95 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 18% |
| Researcher | 12 | 13% |
| Student > Master | 10 | 11% |
| Student > Ph. D. Student | 9 | 9% |
| Lecturer | 4 | 4% |
| Other | 9 | 9% |
| Unknown | 34 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 16% |
| Medicine and Dentistry | 12 | 13% |
| Nursing and Health Professions | 7 | 7% |
| Social Sciences | 4 | 4% |
| Psychology | 3 | 3% |
| Other | 15 | 16% |
| Unknown | 39 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2018.
All research outputs
#7,014,244
of 23,025,074 outputs
Outputs from Current Environmental Health Reports
#191
of 324 outputs
Outputs of similar age
#123,107
of 331,055 outputs
Outputs of similar age from Current Environmental Health Reports
#11
of 19 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 324 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.8. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.