| Title |
Placental transfer of pinazepam and its metabolite N-desmethyldiazepam in women at term
|
|---|---|
| Published in |
European Journal of Clinical Pharmacology, May 1984
|
| DOI | 10.1007/bf00542165 |
| Pubmed ID | |
| Authors |
G. M. Pacifici, L. Cuoci, M. Guarneri, P. Fornaro, G. Arcidiacono, N. Cappelli, G. Moggi, G. F. Placidi |
| Abstract |
Placental transfer of pinazepam and its metabolite N-desmethyldiazepam was investigated in 25 pregnant women at term. Pinazepam was administered orally as a single (10 mg) dose to 13 women, or in multiple doses of 5 mg daily to 12 women. The dose-delivery interval ranged between 1 and 26 h for the single dose, and the period between the last of the multiple doses and delivery was 1.4 to 24 h. Pinazepam and N-desmethyldiazepam were measured in plasma obtained from the umbilical vein and from the mother, at delivery. Pinazepam was only detectable in plasma after the 10 mg dose. The drug did not reach an apparent equilibrium between fetal and maternal plasma. The average (+/- SEM) cord/maternal ratio of plasma pinazepam concentrations was 0.64 +/- 0.07. N-desmethyldiazepam was detectable on each occasion. Its concentration in the plasma from the cord vein became higher than that in the maternal specimens 1-2 h after administration of the parent drug. Little N-desmethyldiazepam was excreted in breast milk. |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 9 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 1 | 11% |
| Student > Bachelor | 1 | 11% |
| Researcher | 1 | 11% |
| Student > Master | 1 | 11% |
| Unknown | 5 | 56% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 1 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 11% |
| Chemistry | 1 | 11% |
| Medicine and Dentistry | 1 | 11% |
| Unknown | 5 | 56% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2023.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from European Journal of Clinical Pharmacology
#951
of 2,744 outputs
Outputs of similar age
#2,388
of 8,558 outputs
Outputs of similar age from European Journal of Clinical Pharmacology
#1
of 4 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,744 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 8,558 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them