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Mendeley readers
Attention Score in Context
| Title |
Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease
|
|---|---|
| Published in |
American Journal of Human Genetics, February 2003
|
| DOI | 10.1086/373937 |
| Pubmed ID | |
| Authors |
Joelle M. van der Walt, Kristin K. Nicodemus, Eden R. Martin, William K. Scott, Martha A. Nance, Ray L. Watts, Jean P. Hubble, Jonathan L. Haines, William C. Koller, Kelly Lyons, Rajesh Pahwa, Matthew B. Stern, Amy Colcher, Bradley C. Hiner, Joseph Jankovic, William G. Ondo, Fred H. Allen, Christopher G. Goetz, Gary W. Small, Frank Mastaglia, Jeffrey M. Stajich, Adam C. McLaurin, Lefkos T. Middleton, Burton L. Scott, Donald E. Schmechel, Margaret A. Pericak-Vance, Jeffery M. Vance |
| Abstract |
Mitochondrial (mt) impairment, particularly within complex I of the electron transport system, has been implicated in the pathogenesis of Parkinson disease (PD). More than half of mitochondrially encoded polypeptides form part of the reduced nicotinamide adenine dinucleotide dehydrogenase (NADH) complex I enzyme. To test the hypothesis that mtDNA variation contributes to PD expression, we genotyped 10 single-nucleotide polymorphisms (SNPs) that define the European mtDNA haplogroups in 609 white patients with PD and 340 unaffected white control subjects. Overall, individuals classified as haplogroup J (odds ratio [OR] 0.55; 95% confidence interval [CI] 0.34-0.91; P=.02) or K (OR 0.52; 95% CI 0.30-0.90; P=.02) demonstrated a significant decrease in risk of PD versus individuals carrying the most common haplogroup, H. Furthermore, a specific SNP that defines these two haplogroups, 10398G, is strongly associated with this protective effect (OR 0.53; 95% CI 0.39-0.73; P=.0001). SNP 10398G causes a nonconservative amino acid change from threonine to alanine within the NADH dehydrogenase 3 (ND3) of complex I. After stratification by sex, this decrease in risk appeared stronger in women than in men (OR 0.43; 95% CI 0.27-0.71; P=.0009). In addition, SNP 9055A of ATP6 demonstrated a protective effect for women (OR 0.45; 95% CI 0.22-0.93; P=.03). Our results suggest that ND3 is an important factor in PD susceptibility among white individuals and could help explain the role of complex I in PD expression. |
Mendeley readers
The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Austria | 2 | 1% |
| Chile | 1 | <1% |
| Italy | 1 | <1% |
| New Zealand | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 186 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 41 | 21% |
| Student > Ph. D. Student | 33 | 17% |
| Student > Master | 25 | 13% |
| Professor > Associate Professor | 17 | 9% |
| Student > Bachelor | 16 | 8% |
| Other | 36 | 19% |
| Unknown | 26 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 54 | 28% |
| Biochemistry, Genetics and Molecular Biology | 39 | 20% |
| Medicine and Dentistry | 33 | 17% |
| Neuroscience | 14 | 7% |
| Psychology | 3 | 2% |
| Other | 13 | 7% |
| Unknown | 38 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2017.
All research outputs
#5,448,088
of 25,377,790 outputs
Outputs from American Journal of Human Genetics
#2,421
of 5,879 outputs
Outputs of similar age
#10,248
of 62,090 outputs
Outputs of similar age from American Journal of Human Genetics
#21
of 69 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,879 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.3. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,090 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.