| Title |
The interplay of histone H2B ubiquitination with budding and fission yeast heterochromatin
|
|---|---|
| Published in |
Current Genetics, February 2018
|
| DOI | 10.1007/s00294-018-0812-1 |
| Pubmed ID | |
| Authors |
Alexis Zukowski, Aaron M. Johnson |
| Abstract |
Mono-ubiquitinated histone H2B (H2B-Ub) is important for chromatin regulation of transcription, chromatin assembly, and also influences heterochromatin. In this review, we discuss the effects of H2B-Ub from nucleosome to higher-order chromatin structure. We then assess what is currently known of the role of H2B-Ub in heterochromatic silencing in budding and fission yeasts (S. cerevisiae and S. pombe), which have distinct silencing mechanisms. In budding yeast, the SIR complex initiates heterochromatin assembly with the aid of a H2B-Ub deubiquitinase, Ubp10. In fission yeast, the RNAi-dependent pathway initiates heterochromatin in the context of low H2B-Ub. We examine how the different silencing machineries overcome the challenge of H2B-Ub chromatin and highlight the importance of using these microorganisms to further our understanding of H2B-Ub in heterochromatic silencing pathways. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 36% |
| Researcher | 11 | 22% |
| Student > Bachelor | 6 | 12% |
| Student > Doctoral Student | 4 | 8% |
| Student > Master | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 6 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 56% |
| Agricultural and Biological Sciences | 15 | 30% |
| Chemistry | 1 | 2% |
| Neuroscience | 1 | 2% |
| Unknown | 5 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2018.
All research outputs
#17,932,482
of 23,025,074 outputs
Outputs from Current Genetics
#930
of 1,203 outputs
Outputs of similar age
#240,510
of 331,055 outputs
Outputs of similar age from Current Genetics
#13
of 20 outputs
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