| Title |
Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans
|
|---|---|
| Published in |
Archives of Toxicology, June 2007
|
| DOI | 10.1007/s00204-007-0215-4 |
| Pubmed ID | |
| Authors |
Andreas Kampkötter, Christiane Gombitang Nkwonkam, Ruben Felix Zurawski, Claudia Timpel, Yvonni Chovolou, Wim Wätjen, Regine Kahl |
| Abstract |
Flavonoids present in many herbal edibles possess a remarkable spectrum of biochemical and pharmacological actions and they are assumed to exert beneficial effects to human health. Although the precise biological mechanisms of their action has not been elucidated yet many of the protective properties of flavonoids are attributed to their antioxidative activity since oxidative stress is regarded as a main factor in the pathophysiology of various diseases and ageing. Oxidative stress results from excessive generation of reactive oxygen species (ROS) or diminished antioxidative defence and thus antioxidants are able to counteract such situations. We used the multicellular model organism Caenorhabditis elegans that is conserved in molecular and cellular pathways to mammals to examine the effects of the flavonoids kaempferol and fisetin with respect to their protective action in individual living worms. Both flavonoids increased the survival of C. elegans, reduced the intracellular ROS accumulation at lethal thermal stress, and diminished the extent of induced oxidative stress with kaempferol having a stronger impact. Kaempferol but not fisetin attenuated the accumulation of the ageing marker lipofuscin suggesting a life prolonging activity of this flavonoid. In addition to these effects that may be attributed to their antioxidative potential kaempferol and fisetin caused a translocation of the C. elegans FoxO transcription factor DAF-16 from the cytosol to the nucleus indicating a modulatory influence of both flavonoids on signalling cascade(s). |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | <1% |
| Netherlands | 1 | <1% |
| China | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 110 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 20% |
| Student > Master | 17 | 15% |
| Researcher | 10 | 9% |
| Student > Bachelor | 10 | 9% |
| Professor | 6 | 5% |
| Other | 25 | 22% |
| Unknown | 24 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 32% |
| Biochemistry, Genetics and Molecular Biology | 24 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
| Medicine and Dentistry | 4 | 3% |
| Environmental Science | 4 | 3% |
| Other | 12 | 10% |
| Unknown | 26 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2012.
All research outputs
#8,354,683
of 24,975,223 outputs
Outputs from Archives of Toxicology
#1,076
of 2,820 outputs
Outputs of similar age
#28,244
of 79,199 outputs
Outputs of similar age from Archives of Toxicology
#4
of 10 outputs
Altmetric has tracked 24,975,223 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,820 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
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We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.