| Title |
Positive effects of fampridine on cognition, fatigue and depression in patients with multiple sclerosis over 2 years
|
|---|---|
| Published in |
Journal of Neurology, February 2018
|
| DOI | 10.1007/s00415-018-8796-9 |
| Pubmed ID | |
| Authors |
Sarah D. Broicher, Linard Filli, Olivia Geisseler, Nicole Germann, Björn Zörner, P. Brugger, M. Linnebank |
| Abstract |
To assess the effects of PR-fampridine on cognitive functioning, fatigue and depression in patients with multiple sclerosis (PwMS). Thirty-two PwMS were included in this trial. Cognitive performance was assessed in an open-label and randomized double-blind, placebo-controlled study design using a comprehensive neuropsychological test battery as well as questionnaires examining depression and fatigue. We found significant improvements in cognitive measures assessing alertness (tonic alertness, p = 0.0244 and phasic alertness, p = 0.0428), psychomotor speed (p = 0.0140) as well as verbal fluency (p = 0.0002) during open-label treatment with PR-fampridine. These effects of performance were paralleled by patients' perception of reduced fatigue (physical, p = 0.0131; cognitive, p = 0.0225; total, p = 0.0126). Fampridine-induced improvements in phasic alertness (p = 0.0010) and measures of fatigue (physical, p = 0.0014; cognitive, p = 0.0003; total, p = 0.0005) were confirmed during randomized, double-blind, placebo-controlled assessment in the second year. In addition, we found positive effects of PR-fampridine on depressive symptoms (p = 0.0049). We demonstrated persisting beneficial effects of PR-fampridine on fatigue in PwMS over a period of more than 2 years. Drug responsiveness regarding cognitive performance and fatigue was not limited to walking responders. Our data demonstrate significant positive effects of treatment with PR-fampridine over 2 years on different cognitive domains as well as fatigue and depression in a cohort of PwMS. These findings imply that PR-fampridine should be considered as symptomatic treatment improving aspects of cognition, fatigue and depression in PwMS. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| United Kingdom | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 110 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 10% |
| Student > Master | 10 | 9% |
| Student > Ph. D. Student | 9 | 8% |
| Student > Postgraduate | 9 | 8% |
| Student > Bachelor | 7 | 6% |
| Other | 25 | 23% |
| Unknown | 39 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 19% |
| Psychology | 15 | 14% |
| Nursing and Health Professions | 9 | 8% |
| Neuroscience | 8 | 7% |
| Social Sciences | 4 | 4% |
| Other | 11 | 10% |
| Unknown | 42 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2021.
All research outputs
#5,127,719
of 25,008,338 outputs
Outputs from Journal of Neurology
#1,342
of 4,904 outputs
Outputs of similar age
#92,201
of 336,650 outputs
Outputs of similar age from Journal of Neurology
#27
of 94 outputs
Altmetric has tracked 25,008,338 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,904 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 72% of its peers.
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We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.