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Mendeley readers
| Title |
Mating-Type Locus of Cryptococcus neoformans: a Step in the Evolution of Sex Chromosomes
|
|---|---|
| Published in |
mSphere, October 2002
|
| DOI | 10.1128/ec.1.5.704-718.2002 |
| Pubmed ID | |
| Authors |
Klaus B. Lengeler, Deborah S. Fox, James A. Fraser, Andria Allen, Keri Forrester, Fred S. Dietrich, Joseph Heitman |
| Abstract |
The sexual development and virulence of the fungal pathogen Cryptococcus neoformans is controlled by a bipolar mating system determined by a single locus that exists in two alleles, alpha and a. The alpha and a mating-type alleles from two divergent varieties were cloned and sequenced. The C. neoformans mating-type locus is unique, spans >100 kb, and contains more than 20 genes. MAT-encoded products include homologs of regulators of sexual development in other fungi, pheromone and pheromone receptors, divergent components of a MAP kinase cascade, and other proteins with no obvious function in mating. The alpha and a alleles of the mating-type locus have extensively rearranged during evolution and strain divergence but are stable during genetic crosses and in the population. The C. neoformans mating-type locus is strikingly different from the other known fungal mating-type loci, sharing features with the self-incompatibility systems and sex chromosomes of algae, plants, and animals. Our study establishes a new paradigm for mating-type loci in fungi with implications for the evolution of cell identity and self/nonself recognition. |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Switzerland | 1 | <1% |
| Malaysia | 1 | <1% |
| Germany | 1 | <1% |
| Italy | 1 | <1% |
| Netherlands | 1 | <1% |
| Argentina | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 99 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 28% |
| Student > Ph. D. Student | 26 | 24% |
| Student > Bachelor | 17 | 16% |
| Student > Master | 10 | 9% |
| Professor > Associate Professor | 5 | 5% |
| Other | 15 | 14% |
| Unknown | 5 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 58 | 54% |
| Biochemistry, Genetics and Molecular Biology | 20 | 19% |
| Immunology and Microbiology | 9 | 8% |
| Medicine and Dentistry | 4 | 4% |
| Chemistry | 2 | 2% |
| Other | 3 | 3% |
| Unknown | 12 | 11% |