| Title |
Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam
|
|---|---|
| Published in |
European Journal of Clinical Pharmacology, January 2006
|
| DOI | 10.1007/s00228-005-0071-1 |
| Pubmed ID | |
| Authors |
Koh-ichi Sugimoto, Nobutaka Araki, Masami Ohmori, Ken-ichi Harada, Yimin Cui, Shuichi Tsuruoka, Atsuhiro Kawaguchi, Akio Fujimura |
| Abstract |
Grapefruit juice (GFJ) inhibits cytochrome P450 (CYP) 3A4 in the gut wall and increases blood concentrations of CYP3A4 substrates by the enhancement of oral bioavailability. The effects of GFJ on two benzodiazepine hypnotics, triazolam (metabolized by CYP3A4) and quazepam (metabolized by CYP3A4 and CYP2C9), were determined in this study. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 3% |
| Mexico | 1 | 3% |
| Unknown | 28 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 23% |
| Student > Bachelor | 5 | 17% |
| Student > Master | 3 | 10% |
| Other | 2 | 7% |
| Student > Doctoral Student | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 8 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 13% |
| Nursing and Health Professions | 2 | 7% |
| Business, Management and Accounting | 2 | 7% |
| Agricultural and Biological Sciences | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 9 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2023.
All research outputs
#1,601,277
of 22,786,691 outputs
Outputs from European Journal of Clinical Pharmacology
#91
of 2,557 outputs
Outputs of similar age
#4,574
of 155,719 outputs
Outputs of similar age from European Journal of Clinical Pharmacology
#1
of 11 outputs
Altmetric has tracked 22,786,691 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,557 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,719 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.