Title |
Tumor‐associated autoantibodies as early detection markers for ovarian cancer? A prospective evaluation
|
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Published in |
International Journal of Cancer, March 2018
|
DOI | 10.1002/ijc.31335 |
Pubmed ID | |
Authors |
Rudolf Kaaks, Renée Turzanski Fortner, Anika Hüsing, Myrto Barrdahl, Marika Hopper, Theron Johnson, Anne Tjønneland, Louise Hansen, Kim Overvad, Agnès Fournier, Marie‐Christine Boutron‐Ruault, Marina Kvaskoff, Laure Dossus, Mattias Johansson, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Carlo La Vecchia, Sabina Sieri, Amalia Mattiello, Domenico Palli, Rosario Tumino, Giuseppe Matullo, N. Charlotte Onland‐Moret, Inger T. Gram, Elisabete Weiderpass, Maria‐Jose Sánchez, Carmen Navarro Sanchez, Eric J. Duell, Eva Ardanaz, Nerea Larranaga, Eva Lundin, Annika Idahl, Karin Jirström, Björn Nodin, Ruth C. Travis, Elio Riboli, Melissa Merritt, Dagfinn Aune, Kathryn Terry, Daniel W. Cramer, Karen S. Anderson |
Abstract |
Immuno-proteomic screening has identified several tumor-associated auto-antibodies (AAb) that may have diagnostic capacity for invasive epithelial ovarian cancer, with AAbs to P53 proteins and cancer-testis antigens (CTAGs) as prominent examples. However, the early detection potential of these AAbs has been insufficiently explored in prospective studies. We performed ELISA measurements of AAbs to CTAG1A, CTAG2, P53, and NUDT11 proteins, for 194 patients with ovarian cancer and 705 matched controls from the European EPIC cohort, using serum samples collected up to 36 months prior to diagnosis under usual care. CA125 was measured using electrochemo-luminiscence. Diagnostic discrimination statistics were calculated by strata of lead-time between blood collection and diagnosis. With lead times ≤6 months, ovarian cancer detection sensitivity at 0.98 specificity (SE98) varied from 0.19 [95% CI 0.08-0.40] for CTAG1A, CTAG2 and NUDT1 to 0.23 [0.10-0.44] for P53 (0.33 [0.11-0.68] for high-grade serous tumors). However, at longer lead-times the ability of these AAb markers to distinguish future ovarian cancer cases from controls declined rapidly; at lead times >1 year, SE98 estimates were close to zero (all invasive cases, range: 0.01-0.11). Compared to CA125 alone, combined logistic regression scores of AAbs and CA125 did not improve detection sensitivity at equal level of specificity. The added value of these selected AAbs as markers for ovarian cancer beyond CA125 for early detection is therefore limited. This article is protected by copyright. All rights reserved. |
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Geographical breakdown
Country | Count | As % |
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Spain | 5 | 56% |
United States | 1 | 11% |
United Kingdom | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 89% |
Scientists | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 14% |
Student > Master | 5 | 12% |
Researcher | 5 | 12% |
Professor > Associate Professor | 3 | 7% |
Student > Ph. D. Student | 3 | 7% |
Other | 5 | 12% |
Unknown | 15 | 36% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 14 | 33% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Agricultural and Biological Sciences | 3 | 7% |
Social Sciences | 2 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 3 | 7% |
Unknown | 15 | 36% |