Title |
Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives
|
---|---|
Published in |
Organic and Biomolecular Chemistry, July 2005
|
DOI | 10.1039/b505069c |
Pubmed ID | |
Authors |
Florence O. McCarthy, Jay Chopra, Alan Ford, Sean A. Hogan, Joe P. Kerry, Nora M. O'Brien, Eileen Ryan, Anita R. Maguire |
Abstract |
Beta-sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 3% |
Unknown | 35 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 17% |
Student > Master | 5 | 14% |
Professor | 4 | 11% |
Researcher | 3 | 8% |
Student > Bachelor | 2 | 6% |
Other | 8 | 22% |
Unknown | 8 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 20 | 56% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Unspecified | 1 | 3% |
Medicine and Dentistry | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 22% |