| Title |
Inhibitory effect of medroxyprogesterone acetate on human liver cytochrome P450 enzymes
|
|---|---|
| Published in |
European Journal of Clinical Pharmacology, April 2006
|
| DOI | 10.1007/s00228-006-0128-9 |
| Pubmed ID | |
| Authors |
Jiang-Wei Zhang, Yong Liu, Wei Li, Da-Cheng Hao, Ling Yang |
| Abstract |
Medroxyprogesterone acetate (MPA), frequently used in contraception and chemotherapy, was involved in a report of drug-drug interaction (DDI) when co-administrated with phenytoin, doxifluridine and cyclophosphamide. In order to clarify the mechanism of such interaction, an in vitro study was undertaken to evaluate MPA's potential to inhibit cytochrome P450 (CYP) enzymes. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 4% |
| Unknown | 25 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 31% |
| Professor | 2 | 8% |
| Student > Ph. D. Student | 2 | 8% |
| Student > Postgraduate | 2 | 8% |
| Student > Master | 2 | 8% |
| Other | 3 | 12% |
| Unknown | 7 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 23% |
| Biochemistry, Genetics and Molecular Biology | 3 | 12% |
| Psychology | 2 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
| Chemistry | 2 | 8% |
| Other | 5 | 19% |
| Unknown | 6 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2008.
All research outputs
#7,453,479
of 22,786,691 outputs
Outputs from European Journal of Clinical Pharmacology
#827
of 2,557 outputs
Outputs of similar age
#23,150
of 66,151 outputs
Outputs of similar age from European Journal of Clinical Pharmacology
#7
of 18 outputs
Altmetric has tracked 22,786,691 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,557 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,151 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.