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Mendeley readers
Attention Score in Context
| Title |
Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT3A) and Nicotinic Acetylcholine Receptors: The Anomalous Binding Properties of Nicotine †
|
|---|---|
| Published in |
Biochemistry, July 2002
|
| DOI | 10.1021/bi020266d |
| Pubmed ID | |
| Authors |
Darren L. Beene, Gabriel S. Brandt, Wenge Zhong, Niki M. Zacharias, Henry A. Lester, Dennis A. Dougherty |
| Abstract |
A series of tryptophan analogues has been introduced into the binding site regions of two ion channels, the ligand-gated nicotinic acetylcholine and serotonin 5-HT(3A) receptors, using unnatural amino acid mutagenesis and heterologous expression in Xenopus oocytes. A cation-pi interaction between serotonin and Trp183 of the serotonin channel 5-HT(3A)R is identified for the first time, precisely locating the ligand-binding site of this receptor. The energetic contribution of the observed cation-pi interaction between a tryptophan and the primary ammonium ion of serotonin is estimated to be approximately 4 kcal/mol, while the comparable interaction with the quaternary ammonium of acetylcholine is approximately 2 kcal/mol. The binding mode of nicotine to the nicotinic receptor of mouse muscle is examined by the same technique and found to differ significantly from that of the natural agonist, acetylcholine. |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Switzerland | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| South Africa | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 112 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 30% |
| Researcher | 21 | 18% |
| Student > Master | 12 | 10% |
| Student > Bachelor | 12 | 10% |
| Student > Doctoral Student | 7 | 6% |
| Other | 19 | 16% |
| Unknown | 13 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 36 | 30% |
| Agricultural and Biological Sciences | 29 | 24% |
| Biochemistry, Genetics and Molecular Biology | 13 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Neuroscience | 5 | 4% |
| Other | 17 | 14% |
| Unknown | 14 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#5,165,711
of 24,397,600 outputs
Outputs from Biochemistry
#2,871
of 22,293 outputs
Outputs of similar age
#7,781
of 45,784 outputs
Outputs of similar age from Biochemistry
#14
of 140 outputs
Altmetric has tracked 24,397,600 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,293 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 45,784 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.