Title |
Two flavonol glycosides from Liparis bootanensis
|
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Published in |
Journal of Natural Medicines, February 2018
|
DOI | 10.1007/s11418-018-1189-7 |
Pubmed ID | |
Authors |
Shuai Huang, Run Wu, Feng Gao, Chunying Li, Xianli Zhou |
Abstract |
Two new flavonol glycosides, bootanenside I and II (1 and 2), along with ten known compounds (3-12), were isolated from whole plant of Liparis bootanensis Griff. Their structures were elucidated on the basis of extensive spectroscopic analyses, including high-resolution electrospray-ionization mass spectrometry (HR-ESIMS) and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR). The cytotoxicity of the compounds was investigated against HCT116 human cancer cell line, revealing that none of them possessed considerable cytotoxic activity. Bioassays of the new metabolites showed that compounds 1 and 2 displayed moderate in vitro antiinflammatory activity by inhibiting expression of inducible nitric oxide synthase (iNOS) protein in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 18% |
Student > Master | 2 | 18% |
Other | 1 | 9% |
Student > Bachelor | 1 | 9% |
Unknown | 5 | 45% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 3 | 27% |
Chemistry | 2 | 18% |
Nursing and Health Professions | 1 | 9% |
Unknown | 5 | 45% |