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Peptide inhibitors of protein kinases—discovery, characterisation and use

Overview of attention for article published in Biochimica et Biophysica Acta (BBA), September 2005
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

patent
10 patents
wikipedia
5 Wikipedia pages

Citations

dimensions_citation
60 Dimensions

Readers on

mendeley
89 Mendeley
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Title
Peptide inhibitors of protein kinases—discovery, characterisation and use
Published in
Biochimica et Biophysica Acta (BBA), September 2005
DOI 10.1016/j.bbapap.2005.07.025
Pubmed ID
Authors

Marie A. Bogoyevitch, Renae K. Barr, Albert J. Ketterman

Abstract

Protein kinases are now the second largest group of drug targets, and most protein kinase inhibitors in clinical development are directed towards the ATP-binding site. However, these inhibitors must compete with high intracellular ATP concentrations and they must discriminate between the ATP-binding sites of all protein kinases as well the other proteins that also utilise ATP. It would therefore be beneficial to target sites on protein kinases other than the ATP-binding site. This review describes the discovery, characterisation and use of peptide inhibitors of protein kinases. In many cases, the development of these peptides has resulted from an understanding of the specific protein-binding partners for a particular protein kinase. In addition, novel peptide sequences have been discovered in library screening approaches and have provided new leads in the discovery and/or design of peptide inhibitors of protein kinases. These approaches are therefore providing exciting new opportunities in the development of ATP non-competitive inhibitors of protein kinases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Serbia 1 1%
Estonia 1 1%
Switzerland 1 1%
Unknown 85 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 21%
Student > Master 18 20%
Researcher 17 19%
Student > Bachelor 8 9%
Student > Postgraduate 5 6%
Other 14 16%
Unknown 8 9%
Readers by discipline Count As %
Chemistry 32 36%
Agricultural and Biological Sciences 24 27%
Biochemistry, Genetics and Molecular Biology 8 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Medicine and Dentistry 3 3%
Other 9 10%
Unknown 10 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2021.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from Biochimica et Biophysica Acta (BBA)
#2,451
of 19,216 outputs
Outputs of similar age
#13,314
of 70,434 outputs
Outputs of similar age from Biochimica et Biophysica Acta (BBA)
#21
of 146 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,216 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,434 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 146 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.