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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Radical prostatectomy and the effect of close surgical margins: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database
|
|---|---|
| Published in |
British Journal of Urology, March 2018
|
| DOI | 10.1111/bju.14178 |
| Pubmed ID | |
| Authors |
Christine Herforth, Sean P. Stroup, Zinan Chen, Lauren E. Howard, Stephen J. Freedland, Daniel M. Moreira, Martha K. Terris, William J. Aronson, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane |
| Abstract |
Positive surgical margins (PSM) after radical prostatectomy (RP) are a significant predictor of biochemical failure and possible disease progression. Close surgical margins (CSM) however represent a diagnostic challenge for surgeons. We sought to evaluate the biochemical recurrence (BCR) patterns among men undergoing RP with specimens having negative, positive, and close surgical margins from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. Men undergoing RP between 1988 and 2015 with known final pathologic margin status were evaluated. The cohort was divided into 3 groups based on margin status; negative, positive, and close. Close margins were defined by distance of tumor ≤1mm from the surgical margin. BCR was defined as PSA >0.2ng/ml, 2 values at 0.2ng/ml, or secondary treatment for an elevated PSA. Predictors of BCR, metastases, and mortality were analyzed using Cox-proportional Hazard models. Of 5,515 men in the SEARCH database, 4,337 (79%) men met criteria for inclusion in the analysis. Of these, 2,063 (48%) had negative margins, 1902 (44%) had positive margins, and 372 (8%) had close margins. On multivariable analysis, relative to negative margins, men with close margins had a higher risk of BCR (HR=1.51, 95%CI=1.25-1.82, P<0.001) but a decreased risk of BCR when compared to those men with positive margins (HR=2.09, 95%CI=1.86-2.36, P<0.001). Metastases, prostate cancer specific mortality (PCSM) and all-cause mortality did not differ based on margin status alone. Management of men with close surgical margins is a diagnostic challenge, with a disease course that is not entirely benign. Evaluation of other known risk factors likely provide greater prognostic value for these men and may ultimately better select those who may benefit from adjuvant therapy. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 13% |
| Student > Bachelor | 3 | 13% |
| Professor > Associate Professor | 3 | 13% |
| Student > Master | 3 | 13% |
| Researcher | 2 | 9% |
| Other | 4 | 17% |
| Unknown | 5 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 39% |
| Sports and Recreations | 1 | 4% |
| Computer Science | 1 | 4% |
| Chemistry | 1 | 4% |
| Engineering | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 10 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2018.
All research outputs
#3,800,330
of 25,382,440 outputs
Outputs from British Journal of Urology
#1,407
of 6,316 outputs
Outputs of similar age
#74,593
of 346,396 outputs
Outputs of similar age from British Journal of Urology
#32
of 87 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,316 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,396 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.