| Title |
The Phosphoenolpyruvate Carboxykinase of Mycobacterium Tuberculosis Induces Strong Cell-Mediated Immune Responses in Mice
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, May 2006
|
| DOI | 10.1007/s11010-006-9119-5 |
| Pubmed ID | |
| Authors |
Keyi Liu, Xuelian Ba, Jinzhi Yu, Jin Li, Qingkuan Wei, Guangdong Han, Guiping Li, Yong Cui |
| Abstract |
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes guanosine or adenosine mononucleotide-dependent reversible conversion of oxaloacetate (OAA) and phosphoenolpyruvate (PEP). Mycobacterium (M) tuberculosis possesses a putative GTP-dependent PEPCK. To analyze the immune responses caused by PEPCK, the effects of PEPCK on the induction of CD4(+) T cells and cytokines such as IFN-gamma, IL-12 and TNF-alpha were evaluated in mice. It was found that the number of CD4(+) T cells was increased in the PEPCK immunized mice although the change of the number of CD8(+) T cells was not significant. The cytokines IFN-gamma, IL-12 and TNF-alpha were increased significantly in the mice immunized with PEPCK than those of incomplete adjuvant. These characteristics were further demonstrated in the mice infected by pckA mutated BCG strain. The results indicate that PEPCK can effectively induce cell-mediated immune response by increasing activity of cytokines and PEPCK may be a promising new subunit vaccine candidate for tuberculosis. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 27% |
| Student > Master | 6 | 23% |
| Student > Doctoral Student | 3 | 12% |
| Researcher | 3 | 12% |
| Student > Postgraduate | 2 | 8% |
| Other | 3 | 12% |
| Unknown | 2 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 35% |
| Biochemistry, Genetics and Molecular Biology | 4 | 15% |
| Immunology and Microbiology | 3 | 12% |
| Environmental Science | 2 | 8% |
| Mathematics | 1 | 4% |
| Other | 5 | 19% |
| Unknown | 2 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2023.
All research outputs
#7,756,853
of 23,578,918 outputs
Outputs from Molecular and Cellular Biochemistry
#435
of 2,368 outputs
Outputs of similar age
#23,525
of 66,975 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#10
of 25 outputs
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