Title |
Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1
|
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Published in |
Journal of Molecular Medicine, January 1998
|
DOI | 10.1007/s001090050202 |
Pubmed ID | |
Authors |
Michal Janitz, Volker Heiser, U. Böttcher, Olfert Landt, R. Lauster |
Abstract |
The human bone morphogenetic protein-1 was originally identified as a protein with the capacity to stimulate bone and cartilage growth in vitro. Its gene sequence identified it as an alternatively spliced human homolog of the Drosophila dorsal-ventral patterning tolloid gene and suggested that it activates transforming growth factor-beta-like molecules by proteolytic cleavage. Its expression pattern and its recently identified activity as a procollagen C proteinase, however, suggest that it has a more general function in the early stages of embryogenesis. This view is strengthened by the previous observation of a third alternatively spliced isoform of the gene, called bone morphogenetic protein 1/His. We now show that the gene is expressed in three additional variants, leading to shorter and slightly modified C-termini. The three variants are preferentially expressed in placenta but show individual differences in their expression profiles in other soft tissues. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 36% |
Professor > Associate Professor | 2 | 18% |
Student > Ph. D. Student | 2 | 18% |
Unknown | 3 | 27% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 55% |
Biochemistry, Genetics and Molecular Biology | 3 | 27% |
Unknown | 2 | 18% |