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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β
|
|---|---|
| Published in |
Stem Cells, March 2018
|
| DOI | 10.1002/stem.2810 |
| Pubmed ID | |
| Authors |
Sarah E. J. Chambers, Christina L. O'Neill, Jasenka Guduric‐Fuchs, Kiran J. McLoughlin, Aaron Liew, Aoife M. Egan, Timothy O'Brien, Alan W. Stitt, Reinhold J. Medina |
| Abstract |
Myeloid angiogenic cells (MACs) promote revascularization through the paracrine release of angiogenic factors and have been harnessed as therapeutic cells for many ischemic diseases. However, their pro-angiogenic properties have been suggested to be diminished in diabetes. This study investigates how the diabetic milieu affects the immunophenotype and function of MACs; both MACs isolated from diabetic conditions, and healthy cells exposed to a diabetic environment to determine the potential of MACs as a cell therapy for diabetic-related ischaemia. MACs were isolated from human peripheral blood and characterized alongside pro-inflammatory macrophages M (LPS+IFNγ) and pro-angiogenic macrophages M (IL4). Functional changes in MACs in response to high-D-glucose were assessed using an in vitro 3D-tubulogenesis assay. Phenotypic changes were determined by gene and protein expression analysis. Additionally, MACs from type 1 diabetic (T1D) patients and corresponding controls were isolated and characterized. Our evidence demonstrates MACs identity as a distinct macrophage subtype that shares M2 pro-angiogenic characteristics, but can be distinguished by CD163hiexpression. High-D-glucose treatment significantly reduced MACs pro-angiogenic capacity, which was associated with a significant increase in IL1β mRNA and protein expression. Inhibition of IL1β abrogated the anti-angiogenic effect induced by high-D-glucose. IL1β was also significantly up-regulated in MACs isolated from T1D patients with microvascular complications compared to T1D patients without microvascular complications or non-diabetic volunteers. This study demonstrates that Type 1 diabetes and diabetic-like conditions impair the pro-angiogenic and therefore regenerative capacity of MACs, and this response is mediated by IL-1β. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| United Kingdom | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 27% |
| Student > Ph. D. Student | 5 | 19% |
| Researcher | 3 | 12% |
| Lecturer | 2 | 8% |
| Student > Master | 2 | 8% |
| Other | 4 | 15% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 31% |
| Agricultural and Biological Sciences | 4 | 15% |
| Biochemistry, Genetics and Molecular Biology | 4 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Unspecified | 1 | 4% |
| Other | 4 | 15% |
| Unknown | 4 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2020.
All research outputs
#13,582,166
of 23,025,074 outputs
Outputs from Stem Cells
#3,026
of 3,914 outputs
Outputs of similar age
#172,522
of 332,334 outputs
Outputs of similar age from Stem Cells
#41
of 58 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,914 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,334 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.