| Title |
Prothrombotic factors do not increase the risk of recurrent ischemic events after cryptogenic stroke at young age: the FUTURE study
|
|---|---|
| Published in |
Journal of Thrombosis and Thrombolysis, February 2018
|
| DOI | 10.1007/s11239-018-1631-4 |
| Pubmed ID | |
| Authors |
Mijntje M. I. Schellekens, Mayte E. van Alebeek, Renate M. Arntz, Nathalie E. Synhaeve, Noortje A. M. M. Maaijwee, Hennie C. Schoonderwaldt, Maureen J. van der Vlugt, Ewoud J. van Dijk, Loes C. A. Rutten-Jacobs, Frank-Erik de Leeuw |
| Abstract |
The role of hypercoagulable states and preceding infections in the etiology of young stroke and their role in developing recurrent ischemic events remains unclear. Our aim is to determine the prevalence of these conditions in patients with cryptogenic stroke at young age and to assess the long-term risk of recurrent ischemic events in patients with and without a hypercoagulable state or a recent pre-stroke infection with Borrelia or Syphilis. We prospectively included patients with a first-ever transient ischemic attack or ischemic stroke, aged 18-50, admitted to our hospital between 1995 and 2010. A retrospective analysis was conducted of prothrombotic factors and preceding infections. Outcome was recurrent ischemic events. Prevalence of prothrombotic factors did not significantly differ between patients with a cryptogenic stroke and with an identified cause (24/120 (20.0%) and 32/174 (18.4%) respectively). In patients with a cryptogenic stroke the long-term risk [mean follow-up of 8.9 years (SD 4.6)] of any recurrent ischemic event or recurrent cerebral ischemia did not significantly differ between patients with and without a hypercoagulable state or a recent infection. In patients with a cryptogenic stroke 15-years cumulative risk of any recurrent ischemic event was 24 and 23% in patients with and without any prothrombotic factor respectively. The prevalence of prothrombotic factors and preceding infections did not significantly differ between stroke patients with a cryptogenic versus an identified cause of stroke and neither is significantly associated with an increased risk of recurrent ischemic events after cryptogenic stroke. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 2 | 8% |
| Student > Master | 2 | 8% |
| Researcher | 2 | 8% |
| Professor | 2 | 8% |
| Lecturer | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 12 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 29% |
| Immunology and Microbiology | 2 | 8% |
| Agricultural and Biological Sciences | 1 | 4% |
| Social Sciences | 1 | 4% |
| Neuroscience | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 12 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2018.
All research outputs
#16,499,946
of 25,069,047 outputs
Outputs from Journal of Thrombosis and Thrombolysis
#659
of 1,056 outputs
Outputs of similar age
#206,826
of 335,904 outputs
Outputs of similar age from Journal of Thrombosis and Thrombolysis
#13
of 22 outputs
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