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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Heritable DNA methylation marks associated with susceptibility to breast cancer
|
|---|---|
| Published in |
Nature Communications, February 2018
|
| DOI | 10.1038/s41467-018-03058-6 |
| Pubmed ID | |
| Authors |
Jihoon E. Joo, James G. Dowty, Roger L. Milne, Ee Ming Wong, Pierre-Antoine Dugué, Dallas English, John L. Hopper, David E. Goldgar, Graham G. Giles, Melissa C. Southey, kConFab |
| Abstract |
Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable methylation marks associated with breast cancer susceptibility by studying 25 Australian multiple-case breast cancer families. Here we report genome-wide DNA methylation measured in 210 peripheral blood DNA samples provided by family members using the Infinium HumanMethylation450. We develop and apply a new statistical method to identify heritable methylation marks based on complex segregation analysis. We estimate carrier probabilities for the 1000 most heritable methylation marks based on family structure, and we use Cox proportional hazards survival analysis to identify 24 methylation marks with corresponding carrier probabilities significantly associated with breast cancer. We replicate an association with breast cancer risk for four of the 24 marks using an independent nested case-control study. Here, we report a novel approach for identifying heritable DNA methylation marks associated with breast cancer risk. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 25% |
| Canada | 2 | 7% |
| United Kingdom | 2 | 7% |
| France | 1 | 4% |
| Italy | 1 | 4% |
| Spain | 1 | 4% |
| Germany | 1 | 4% |
| Turkey | 1 | 4% |
| Japan | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 9 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 71% |
| Scientists | 6 | 21% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 13% |
| Student > Master | 5 | 8% |
| Student > Bachelor | 5 | 8% |
| Other | 4 | 7% |
| Student > Doctoral Student | 3 | 5% |
| Other | 14 | 23% |
| Unknown | 22 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 28% |
| Agricultural and Biological Sciences | 5 | 8% |
| Medicine and Dentistry | 4 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Nursing and Health Professions | 1 | 2% |
| Other | 6 | 10% |
| Unknown | 26 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 139. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2020.
All research outputs
#283,850
of 24,597,084 outputs
Outputs from Nature Communications
#4,252
of 53,069 outputs
Outputs of similar age
#6,693
of 335,040 outputs
Outputs of similar age from Nature Communications
#108
of 1,209 outputs
Altmetric has tracked 24,597,084 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 53,069 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,040 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,209 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.