| Title |
The SLC4 family of HCO3− transporters
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, January 2004
|
| DOI | 10.1007/s00424-003-1180-2 |
| Pubmed ID | |
| Authors |
Michael F. Romero, Christiaan M. Fulton, Walter F. Boron |
| Abstract |
The SLC4 family consists of ten genes. All appear to encode integral membrane proteins with very similar hydropathy plots-consistent with the presence of 10-14 transmembrane segments. At least eight SLC4 members encode proteins that transport HCO(3)(-) (or a related species, such as CO(3)(2-)) across the plasma membrane. Functionally, these eight proteins fall into two major groups: three Cl-HCO(3) exchangers (AE1-3) and five Na(+)-coupled HCO(3)(-) transporters (NBCe1, NBCe2, NBCn1, NDCBE, NCBE). Two of the Na(+)-coupled HCO(3)(- )transporters (NBCe1, NBCe2) are electrogenic; the other three Na(+)-coupled HCO(3)(-) transporters and all three AEs are electroneutral. At least NDCBE transports Cl(-) in addition to Na(+) and HCO(3)(-). Whether NCBE transports Cl(-)-in addition to Na(+) and HCO(3)(-)-is unsettled. In addition, two other SLC4 members (AE4 and BTR1) do not yet have a firmly established function; on the basis of homology, they fall between the two major groups. A characteristic of many, though not all, SLC4 members is inhibition by 4,4'-diisothiocyanatostilbene-2,2'-disulfonate (DIDS). SLC4 gene products play important roles in the carriage of CO(2) by erythrocytes, the absorption or secretion of H(+) or HCO(3)(-) by several epithelia, as well as the regulation of cell volume and intracellular pH. |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Portugal | 1 | <1% |
| Switzerland | 1 | <1% |
| Germany | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 140 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 39 | 27% |
| Student > Ph. D. Student | 34 | 23% |
| Student > Bachelor | 17 | 12% |
| Student > Master | 12 | 8% |
| Student > Doctoral Student | 9 | 6% |
| Other | 25 | 17% |
| Unknown | 11 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 75 | 51% |
| Biochemistry, Genetics and Molecular Biology | 21 | 14% |
| Medicine and Dentistry | 12 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Neuroscience | 5 | 3% |
| Other | 15 | 10% |
| Unknown | 13 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2022.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#512
of 2,055 outputs
Outputs of similar age
#37,509
of 146,230 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#2
of 8 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,055 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,230 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.