| Title |
SLC19: the folate/thiamine transporter family
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, May 2003
|
| DOI | 10.1007/s00424-003-1068-1 |
| Pubmed ID | |
| Authors |
Vadivel Ganapathy, Sylvia B. Smith, Puttur D. Prasad |
| Abstract |
The SLC19 gene family of solute carriers is a family of three transporter proteins with significant structural similarity, transporting, however, substrates with different structure and ionic charge. The three members of this gene family are expressed ubiquitously and mediate the transport of two important water-soluble vitamins, folate and thiamine. The concentrative transport of substrates mediated by the members of this gene family is energized by transcellular H(+)/OH(-) gradient. SLC19A1 is expressed at highest levels in absorptive cells where it is located in a polarized manner either in the apical or basal membrane, depending on the cell type. It mediates the transport of reduced folate and its analogs, such as methotrexate, which are anionic at physiological pH. SLC19A2 is expressed ubiquitously and mediates the transport of thiamine, a cation at physiological pH. SLC19A3 is also widely expressed and is capable of transporting thiamine. This review summarizes the current knowledge on the structural, functional, molecular and physiological aspects of the SLC19 gene family. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Poland | 1 | 1% |
| Denmark | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 84 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 23% |
| Researcher | 15 | 17% |
| Student > Bachelor | 10 | 11% |
| Student > Master | 8 | 9% |
| Other | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 19 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 30% |
| Medicine and Dentistry | 13 | 15% |
| Biochemistry, Genetics and Molecular Biology | 13 | 15% |
| Neuroscience | 6 | 7% |
| Chemistry | 5 | 6% |
| Other | 7 | 8% |
| Unknown | 18 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2023.
All research outputs
#2,759,955
of 25,374,647 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#82
of 2,055 outputs
Outputs of similar age
#3,640
of 54,766 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#1
of 29 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,055 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 54,766 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.