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MicroRNA meta-signature of oral cancer: evidence from a meta-analysis

Overview of attention for article published in Upsala Journal of Medical Sciences, February 2018
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Title
MicroRNA meta-signature of oral cancer: evidence from a meta-analysis
Published in
Upsala Journal of Medical Sciences, February 2018
DOI 10.1080/03009734.2018.1439551
Pubmed ID
Authors

Katarina Zeljic, Ivan Jovanovic, Jasmina Jovanovic, Zvonko Magic, Aleksandra Stankovic, Gordana Supic

Abstract

It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 56 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 18%
Student > Master 9 16%
Student > Ph. D. Student 6 11%
Student > Doctoral Student 6 11%
Student > Bachelor 4 7%
Other 10 18%
Unknown 11 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 21%
Medicine and Dentistry 12 21%
Agricultural and Biological Sciences 5 9%
Immunology and Microbiology 3 5%
Nursing and Health Professions 1 2%
Other 6 11%
Unknown 17 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2018.
All research outputs
#18,589,103
of 23,025,074 outputs
Outputs from Upsala Journal of Medical Sciences
#295
of 365 outputs
Outputs of similar age
#256,746
of 330,211 outputs
Outputs of similar age from Upsala Journal of Medical Sciences
#3
of 5 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 365 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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