Title |
Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance)
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Published in |
Journal of Clinical Oncology, February 2018
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DOI | 10.1200/jco.2017.75.5413 |
Pubmed ID | |
Authors |
Temidayo Fadelu, Sui Zhang, Donna Niedzwiecki, Xing Ye, Leonard B. Saltz, Robert J. Mayer, Rex B. Mowat, Renaud Whittom, Alexander Hantel, Al B. Benson, Daniel M. Atienza, Michael Messino, Hedy L. Kindler, Alan Venook, Shuji Ogino, Kimmie Ng, Kana Wu, Walter Willett, Edward Giovannucci, Jeffrey Meyerhardt, Ying Bao, Charles S. Fuchs |
Abstract |
Purpose Observational studies have reported increased colon cancer recurrence and mortality in patients with states of hyperinsulinemia, including type 2 diabetes, obesity, sedentary lifestyle, and high glycemic load diet. Nut intake has been associated with a lower risk of type 2 diabetes, metabolic syndrome, and insulin resistance. However, the effect of nut intake on colon cancer recurrence and survival is not known. Patients and Methods We conducted a prospective, observational study of 826 eligible patients with stage III colon cancer who reported dietary intake on food frequency questionnaires while enrolled onto a randomized adjuvant chemotherapy trial. Using Cox proportional hazards regression, we assessed associations of nut intake with cancer recurrence and mortality. Results After a median follow-up of 6.5 years, compared with patients who abstained from nuts, individuals who consumed two or more servings of nuts per week experienced an adjusted hazard ratio (HR) for disease-free survival of 0.58 (95% CI, 0.37 to 0.92; Ptrend= .03) and an HR for overall survival of 0.43 (95% CI, 0.25 to 0.74; Ptrend= .01). In subgroup analysis, the apparent benefit was confined to tree nut intake (HR for disease-free survival, 0.54; 95% CI, 0.34 to 0.85; Ptrend= .04; and HR for overall survival, 0.47; 95% CI, 0.27 to 0.82; Ptrend= .04). The association of total nut intake with improved outcomes was maintained across other known or suspected risk factors for cancer recurrence and mortality. Conclusion Diets with a higher consumption of nuts may be associated with a significantly reduced incidence of cancer recurrence and death in patients with stage III colon cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 34 | 16% |
Japan | 26 | 12% |
United Kingdom | 10 | 5% |
Spain | 8 | 4% |
France | 7 | 3% |
Canada | 4 | 2% |
Australia | 3 | 1% |
Brazil | 3 | 1% |
India | 3 | 1% |
Other | 24 | 11% |
Unknown | 92 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 184 | 86% |
Practitioners (doctors, other healthcare professionals) | 15 | 7% |
Scientists | 11 | 5% |
Science communicators (journalists, bloggers, editors) | 4 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 176 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 22 | 13% |
Researcher | 21 | 12% |
Student > Bachelor | 21 | 12% |
Other | 15 | 9% |
Student > Ph. D. Student | 13 | 7% |
Other | 34 | 19% |
Unknown | 50 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 54 | 31% |
Nursing and Health Professions | 27 | 15% |
Agricultural and Biological Sciences | 7 | 4% |
Biochemistry, Genetics and Molecular Biology | 6 | 3% |
Unspecified | 6 | 3% |
Other | 16 | 9% |
Unknown | 60 | 34% |